Successful allogeneic hematopoietic stem cell transplantation for aggressive NK cell Leukemia

Satoshi Ichikawa, Noriko Fukuhara, Joji Yamamoto, Makiko Suzuki, Shinji Nakajima, Yoko Okitsu, Katsura Kohata, Yasushi Onishi, Kenichi Ishizawa, Junichi Kameoka, Hideo Harigae

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Aggressive natural killer cell leukemia (ANKL) is a highly aggressive lymphoproliferative disease. An appropriate therapeutic strategy for ANKL remains to be established, but a few case reports have suggested that allogeneic hematopoietic stem cell transplantation (allo-HCT) can be curative. Here, we report a young woman with ANKL showing central nervous system (CNS) invasion, who has been in complete remission for more than a year after allo-HCT following two courses of intravenous chemotherapy and several rounds of intrathecal chemotherapy. Intensive remission induction chemotherapy followed by conventional myeloablative allo-HCT is a promising approach for long-term remission in cases of this aggressive malignancy.

Original languageEnglish
Pages (from-to)1907-1910
Number of pages4
JournalInternal Medicine
Issue number17
Publication statusPublished - 2010


  • Aggressive NK cell leukemia
  • Allogeneic hematopoietic stem cell transplantation
  • Central nervous system invasion
  • L-asparaginase
  • Subarachnoid hemorrhage


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