Successful treatment of aggressive mature B-cell lymphoma mimicking immune thrombocytopenic purpura

Koya Ono, Yasushi Onishi, Masahiro Kobayashi, Satoshi Ichikawa, Shunsuke Hatta, Shotaro Watanabe, Yoko Okitsu, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A 55-year-old woman suffered from hemorrhagic tendency. She had severe thrombocytopenia without any hematological or coagulatory abnormalities, and a bone marrow examination revealed an increased number of megakaryocytes without any abnormal cells or blasts. No lymphadenopathy or hepatosplenomegaly was observed on computed tomography. She was initially diagnosed with immune thrombocytopenic purpura (ITP). None of the treatments administered for ITP produced a response. However, abnormal cells were eventually found during the third bone marrow examination. The pathological diagnosis was mature B-cell lymphoma. Rituximab-containing chemotherapy produced a marked increase in the patient’s platelet count, and her lymphoma went into complete remission.

Original languageEnglish
Pages (from-to)2573-2579
Number of pages7
JournalInternal Medicine
Issue number17
Publication statusPublished - 2018


  • Diffuse large B-cell lymphoma
  • Immune thrombocytopenic purpura
  • R-CHOP therapy


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