Successful treatment of aggressive mature B-cell lymphoma mimicking immune thrombocytopenic purpura

Koya Ono; Yasushi Onishi; Masahiro Kobayashi; Satoshi Ichikawa; Shunsuke Hatta; Shotaro Watanabe; Yoko Okitsu; Noriko Fukuhara; Ryo Ichinohasama; Hideo Harigae

doi:10.2169/internalmedicine.0560-17

Successful treatment of aggressive mature B-cell lymphoma mimicking immune thrombocytopenic purpura

Koya Ono, Yasushi Onishi, Masahiro Kobayashi, Satoshi Ichikawa, Shunsuke Hatta, Shotaro Watanabe, Yoko Okitsu, Noriko Fukuhara, Ryo Ichinohasama, Hideo Harigae

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A 55-year-old woman suffered from hemorrhagic tendency. She had severe thrombocytopenia without any hematological or coagulatory abnormalities, and a bone marrow examination revealed an increased number of megakaryocytes without any abnormal cells or blasts. No lymphadenopathy or hepatosplenomegaly was observed on computed tomography. She was initially diagnosed with immune thrombocytopenic purpura (ITP). None of the treatments administered for ITP produced a response. However, abnormal cells were eventually found during the third bone marrow examination. The pathological diagnosis was mature B-cell lymphoma. Rituximab-containing chemotherapy produced a marked increase in the patient’s platelet count, and her lymphoma went into complete remission.

Original language	English
Pages (from-to)	2573-2579
Number of pages	7
Journal	Internal Medicine
Volume	57
Issue number	17
DOIs	https://doi.org/10.2169/internalmedicine.0560-17
Publication status	Published - 2018

Keywords

Diffuse large B-cell lymphoma
Immune thrombocytopenic purpura
R-CHOP therapy

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10.2169/internalmedicine.0560-17

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title = "Successful treatment of aggressive mature B-cell lymphoma mimicking immune thrombocytopenic purpura",

abstract = "A 55-year-old woman suffered from hemorrhagic tendency. She had severe thrombocytopenia without any hematological or coagulatory abnormalities, and a bone marrow examination revealed an increased number of megakaryocytes without any abnormal cells or blasts. No lymphadenopathy or hepatosplenomegaly was observed on computed tomography. She was initially diagnosed with immune thrombocytopenic purpura (ITP). None of the treatments administered for ITP produced a response. However, abnormal cells were eventually found during the third bone marrow examination. The pathological diagnosis was mature B-cell lymphoma. Rituximab-containing chemotherapy produced a marked increase in the patient{\textquoteright}s platelet count, and her lymphoma went into complete remission.",

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T1 - Successful treatment of aggressive mature B-cell lymphoma mimicking immune thrombocytopenic purpura

AU - Ono, Koya

AU - Onishi, Yasushi

AU - Kobayashi, Masahiro

AU - Ichikawa, Satoshi

AU - Hatta, Shunsuke

AU - Watanabe, Shotaro

AU - Okitsu, Yoko

AU - Fukuhara, Noriko

AU - Ichinohasama, Ryo

AU - Harigae, Hideo

PY - 2018

Y1 - 2018

N2 - A 55-year-old woman suffered from hemorrhagic tendency. She had severe thrombocytopenia without any hematological or coagulatory abnormalities, and a bone marrow examination revealed an increased number of megakaryocytes without any abnormal cells or blasts. No lymphadenopathy or hepatosplenomegaly was observed on computed tomography. She was initially diagnosed with immune thrombocytopenic purpura (ITP). None of the treatments administered for ITP produced a response. However, abnormal cells were eventually found during the third bone marrow examination. The pathological diagnosis was mature B-cell lymphoma. Rituximab-containing chemotherapy produced a marked increase in the patient’s platelet count, and her lymphoma went into complete remission.

AB - A 55-year-old woman suffered from hemorrhagic tendency. She had severe thrombocytopenia without any hematological or coagulatory abnormalities, and a bone marrow examination revealed an increased number of megakaryocytes without any abnormal cells or blasts. No lymphadenopathy or hepatosplenomegaly was observed on computed tomography. She was initially diagnosed with immune thrombocytopenic purpura (ITP). None of the treatments administered for ITP produced a response. However, abnormal cells were eventually found during the third bone marrow examination. The pathological diagnosis was mature B-cell lymphoma. Rituximab-containing chemotherapy produced a marked increase in the patient’s platelet count, and her lymphoma went into complete remission.

KW - Diffuse large B-cell lymphoma

KW - Immune thrombocytopenic purpura

KW - R-CHOP therapy

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JF - Internal Medicine

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ER -

Successful treatment of aggressive mature B-cell lymphoma mimicking immune thrombocytopenic purpura

Abstract

Keywords

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