Successful treatment of MMP-9-expressing angiosarcoma with low-dose docetaxel and bisphosphonate

Masaya Ishibashi; Taku Fujimura; Akira Hashimoto; Takahiro Haga; Kaoru Onami; Akira Tsukada; Yumi Kambayashi; Takanori Hidaka; Sadanori Furudate; Ryoko Shimada; Setsuya Aiba

doi:10.1159/000335999

Successful treatment of MMP-9-expressing angiosarcoma with low-dose docetaxel and bisphosphonate

Masaya Ishibashi, Taku Fujimura, Akira Hashimoto, Takahiro Haga, Kaoru Onami, Akira Tsukada, Yumi Kambayashi, Takanori Hidaka, Sadanori Furudate, Ryoko Shimada, Setsuya Aiba

Tohoku University

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m ² body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.

Original language	English
Pages (from-to)	5-9
Number of pages	5
Journal	Case Reports in Dermatology
Volume	4
Issue number	1
DOIs	https://doi.org/10.1159/000335999
Publication status	Published - 2012 Jan

Keywords

Angiosarcoma
Bisphosphonate
Docetaxel
MMP-9

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10.1159/000335999

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abstract = "We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m 2 body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.",

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AU - Ishibashi, Masaya

AU - Fujimura, Taku

AU - Hashimoto, Akira

AU - Haga, Takahiro

AU - Onami, Kaoru

AU - Tsukada, Akira

AU - Kambayashi, Yumi

AU - Hidaka, Takanori

AU - Furudate, Sadanori

AU - Shimada, Ryoko

AU - Aiba, Setsuya

PY - 2012/1

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N2 - We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m 2 body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.

AB - We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m 2 body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.

KW - Angiosarcoma

KW - Bisphosphonate

KW - Docetaxel

KW - MMP-9

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Successful treatment of MMP-9-expressing angiosarcoma with low-dose docetaxel and bisphosphonate

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Keywords

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