Successful treatment of MMP-9-expressing angiosarcoma with low-dose docetaxel and bisphosphonate

Masaya Ishibashi, Taku Fujimura, Akira Hashimoto, Takahiro Haga, Kaoru Onami, Akira Tsukada, Yumi Kambayashi, Takanori Hidaka, Sadanori Furudate, Ryoko Shimada, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


We describe a 78-year-old Japanese patient with angiosarcoma on the scalp. Interestingly, immunohistochemical staining revealed this tumor as positive for matrix metalloproteinase 9 (MMP-9). After conventional therapy for angiosarcoma with surgical treatment and radiation therapy, we intravenously administered docetaxel at 40 mg/m 2 body surface area together with oral administration of 17.5 mg sodium risedronate hydrate. One and a half years after the standard treatment, there was no evidence of local recurrence or metastasis.

Original languageEnglish
Pages (from-to)5-9
Number of pages5
JournalCase Reports in Dermatology
Issue number1
Publication statusPublished - 2012 Jan


  • Angiosarcoma
  • Bisphosphonate
  • Docetaxel
  • MMP-9


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