Successful treatment of multiple in-transit melanomas on the leg with intensity-modulated radiotherapy and immune checkpoint inhibitors: Report of two cases

Taku Fujimura; Yumi Kambayashi; Sadanori Furudate; Takanori Hidaka; Yota Sato; Kayo Tanita; Hisayuki Tono; Akira Tsukada; Akira Hashimoto; Setsuya Aiba

doi:10.1111/1346-8138.13707

Successful treatment of multiple in-transit melanomas on the leg with intensity-modulated radiotherapy and immune checkpoint inhibitors: Report of two cases

Taku Fujimura, Yumi Kambayashi, Sadanori Furudate, Takanori Hidaka, Yota Sato, Kayo Tanita, Hisayuki Tono, Akira Tsukada, Akira Hashimoto, Setsuya Aiba

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Because the efficacy rates of monotherapy with immune checkpoint inhibitors such as nivolumab or ipilimumab are not sufficient, to enhance the antitumor effects of these reagents is of great interest among dermato-oncologists. In this report, we describe two cases of multiple in-transit metastatic melanomas on the leg successfully treated with intensity-modulated radiotherapy (IMRT) using a CyberKnife in combination with ipilimumab or nivolumab. Our cases suggested that IMRT could enhance the antitumor effects of immune checkpoint inhibitors in patients with multiple in-transit melanomas.

Original language	English
Pages (from-to)	592-595
Number of pages	4
Journal	Journal of Dermatology
Volume	44
Issue number	5
DOIs	https://doi.org/10.1111/1346-8138.13707
Publication status	Published - 2017 May

Keywords

immune checkpoints inhibitors
in-transit melanoma
intensity-modulated radiotherapy
ipilimumab
nivolumab

ASJC Scopus subject areas

Dermatology

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10.1111/1346-8138.13707

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Fujimura, T., Kambayashi, Y., Furudate, S., Hidaka, T., Sato, Y., Tanita, K., Tono, H., Tsukada, A., Hashimoto, A., & Aiba, S. (2017). Successful treatment of multiple in-transit melanomas on the leg with intensity-modulated radiotherapy and immune checkpoint inhibitors: Report of two cases. Journal of Dermatology, 44(5), 592-595. https://doi.org/10.1111/1346-8138.13707

Fujimura, T , Kambayashi, Y , Furudate, S , Hidaka, T, Sato, Y, Tanita, K, Tono, H, Tsukada, A, Hashimoto, A & Aiba, S 2017, 'Successful treatment of multiple in-transit melanomas on the leg with intensity-modulated radiotherapy and immune checkpoint inhibitors: Report of two cases', Journal of Dermatology, vol. 44, no. 5, pp. 592-595. https://doi.org/10.1111/1346-8138.13707

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AU - Hidaka, Takanori

AU - Sato, Yota

AU - Tanita, Kayo

AU - Tono, Hisayuki

AU - Tsukada, Akira

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AB - Because the efficacy rates of monotherapy with immune checkpoint inhibitors such as nivolumab or ipilimumab are not sufficient, to enhance the antitumor effects of these reagents is of great interest among dermato-oncologists. In this report, we describe two cases of multiple in-transit metastatic melanomas on the leg successfully treated with intensity-modulated radiotherapy (IMRT) using a CyberKnife in combination with ipilimumab or nivolumab. Our cases suggested that IMRT could enhance the antitumor effects of immune checkpoint inhibitors in patients with multiple in-transit melanomas.

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Successful treatment of multiple in-transit melanomas on the leg with intensity-modulated radiotherapy and immune checkpoint inhibitors: Report of two cases

Abstract

Keywords

ASJC Scopus subject areas

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