Successful treatment of plasmacytosis circumorificialis with topical tacrolimus: Two case reports and an immunohistochemical study

Taku Fujimura; Sadanori Furudate; Masaya Ishibashi; Yumi Kambayashi; Gen Ichi Tojo; Chihiro Wakusawa; Hiroshi Mayama; Setsuya Aiba

doi:10.1159/000350184

Successful treatment of plasmacytosis circumorificialis with topical tacrolimus: Two case reports and an immunohistochemical study

Taku Fujimura, Sadanori Furudate, Masaya Ishibashi, Yumi Kambayashi, Gen Ichi Tojo, Chihiro Wakusawa, Hiroshi Mayama, Setsuya Aiba

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163 ⁺ proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.

Original language	English
Pages (from-to)	79-83
Number of pages	5
Journal	Case Reports in Dermatology
Volume	5
Issue number	1
DOIs	https://doi.org/10.1159/000350184
Publication status	Published - 2013 Jan

Keywords

CD163 macrophages
IL-17
Plasmacytosis circumorificialis
Proinflammatory cytokine
Tacrolimus

ASJC Scopus subject areas

Dermatology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163 + proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.",

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author = "Taku Fujimura and Sadanori Furudate and Masaya Ishibashi and Yumi Kambayashi and Tojo, {Gen Ichi} and Chihiro Wakusawa and Hiroshi Mayama and Setsuya Aiba",

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T1 - Successful treatment of plasmacytosis circumorificialis with topical tacrolimus

T2 - Two case reports and an immunohistochemical study

AU - Fujimura, Taku

AU - Furudate, Sadanori

AU - Ishibashi, Masaya

AU - Kambayashi, Yumi

AU - Tojo, Gen Ichi

AU - Wakusawa, Chihiro

AU - Mayama, Hiroshi

AU - Aiba, Setsuya

PY - 2013/1

Y1 - 2013/1

N2 - Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163 + proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.

AB - Plasmacytosis circumorificialis (PLC), a benign chronic inflammatory disease with an unknown pathogenesis, is characterized by erythema, erosion nodules and ulcers around the openings of the human body. In this report, we describe two cases of PLC successfully treated with topical tacrolimus. Interestingly, immunohistochemical staining revealed that prominent CD163 + proinflammatory macrophages and IL-17-producing cells were infiltrating around plasma cells, which might suggest the reason for the therapeutic effect of topical tacrolimus on PLC.

KW - CD163 macrophages

KW - IL-17

KW - Plasmacytosis circumorificialis

KW - Proinflammatory cytokine

KW - Tacrolimus

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Successful treatment of plasmacytosis circumorificialis with topical tacrolimus: Two case reports and an immunohistochemical study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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