TY - JOUR
T1 - Sulfur-utilizing cytoprotection and energy metabolism
AU - Motohashi, Hozumi
AU - Akaike, Takaaki
N1 - Funding Information:
We thank Judith B. Gandy for her excellent editing of the manuscript. This work was supported in part by Grants-in-Aid for Scientific Research ( 17F17116 and 18H02621 to H.M.; 18H05277 to T.A.) and a Grant-in-Aid for Scientific Research on Innovative Areas ( 26111008 to T.A.) from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan, and by AMED under grant number JP18gm5010002 (H.M.). The funders had no role in study design, data collection, and analysis, decision to publish, or manuscript preparation.
Publisher Copyright:
© 2019
PY - 2019/6
Y1 - 2019/6
N2 - Sulfur, one of the most abundant chemical elements on earth, has had important roles in biosphere evolution. Unique roles of sulfur in living organisms are mainly related to the redox reaction, whose functions include cytoprotection and energy metabolism. KEAP1–NRF2 system is a sulfur-utilizing cytoprotection mechanism, and its role in metabolic regulation has been attracting increasing attention. Persulfides, which have rapidly emerged as common biomolecules, also play important roles in cytoprotection and mitochondrial energy metabolism. Chemical regulation by persulfides and transcriptional regulation by the KEAP1–NRF2 system act in concert and make up a sulfur-utilizing dual system for cytoprotection and energy metabolism. Clarification of this system is expected to promote understanding of the aging process in organisms and aging-related diseases.
AB - Sulfur, one of the most abundant chemical elements on earth, has had important roles in biosphere evolution. Unique roles of sulfur in living organisms are mainly related to the redox reaction, whose functions include cytoprotection and energy metabolism. KEAP1–NRF2 system is a sulfur-utilizing cytoprotection mechanism, and its role in metabolic regulation has been attracting increasing attention. Persulfides, which have rapidly emerged as common biomolecules, also play important roles in cytoprotection and mitochondrial energy metabolism. Chemical regulation by persulfides and transcriptional regulation by the KEAP1–NRF2 system act in concert and make up a sulfur-utilizing dual system for cytoprotection and energy metabolism. Clarification of this system is expected to promote understanding of the aging process in organisms and aging-related diseases.
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U2 - 10.1016/j.cophys.2019.03.003
DO - 10.1016/j.cophys.2019.03.003
M3 - Review article
AN - SCOPUS:85064568347
SN - 2468-8681
VL - 9
SP - 1
EP - 8
JO - Current Opinion in Physiology
JF - Current Opinion in Physiology
ER -