[18F]FDG synthesis by Anatech RB-86 robotic system: Improvements and general considerations

A. Bogni, C. Pascali, R. Iwata, A. Cavalleri, V. De Sanctis, D. Decise, G. Cucchetti, F. Crippa, C. Chiesa, M. Schiavini, E. Bombardieri

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, "one-pot" reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalJournal of Radioanalytical and Nuclear Chemistry
Issue number1-2
Publication statusPublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Nuclear Energy and Engineering
  • Radiology Nuclear Medicine and imaging
  • Pollution
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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