[18F]FDG synthesis by Anatech RB-86 robotic system: Improvements and general considerations

A. Bogni; C. Pascali; R. Iwata; A. Cavalleri; V. De Sanctis; D. Decise; G. Cucchetti; F. Crippa; C. Chiesa; M. Schiavini; E. Bombardieri

doi:10.1007/bf02387445

[¹⁸F]FDG synthesis by Anatech RB-86 robotic system: Improvements and general considerations

A. Bogni, C. Pascali, R. Iwata, A. Cavalleri, V. De Sanctis, D. Decise, G. Cucchetti, F. Crippa, C. Chiesa, M. Schiavini, E. Bombardieri

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

A series of changes and updatings to the [¹⁸F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [¹⁸O]H₂O recovery, "one-pot" reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.

Original language	English
Pages (from-to)	45-51
Number of pages	7
Journal	Journal of Radioanalytical and Nuclear Chemistry
Volume	230
Issue number	1-2
DOIs	https://doi.org/10.1007/bf02387445
Publication status	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Nuclear Energy and Engineering
Radiology Nuclear Medicine and imaging
Pollution
Spectroscopy
Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/bf02387445

Cite this

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title = "[18F]FDG synthesis by Anatech RB-86 robotic system: Improvements and general considerations",

abstract = "A series of changes and updatings to the [18F]FDG setup of the Anatech RB-86 robotic system are described. They include improved [18O]H2O recovery, {"}one-pot{"} reaction, elimination of the SPE step and base-assisted hydrolysis. Considerations on this last point are also reported. Thus, a remarkable improvement in the radiochemical yield, which is now 81% (decay corrected to SOS) with a synthesis time of just 40 minutes, has been achieved. The influence of several different reaction vessel materials on the synthesis is also briefly examined.",

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T1 - [18F]FDG synthesis by Anatech RB-86 robotic system

T2 - Improvements and general considerations

AU - Bogni, A.

AU - Pascali, C.

AU - Iwata, R.

AU - Cavalleri, A.

AU - De Sanctis, V.

AU - Decise, D.

AU - Cucchetti, G.

AU - Crippa, F.

AU - Chiesa, C.

AU - Schiavini, M.

AU - Bombardieri, E.

PY - 1998

Y1 - 1998

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