[18F]fluoride production with a circulating [18O]water target

Ren Iwata; Tatsuo Ido; Frank Brady; Toshihiro Takahashi; Akira Ujiie

doi:10.1016/0883-2889(87)90272-3

[¹⁸F]fluoride production with a circulating [¹⁸O]water target

Ren Iwata, Tatsuo Ido, Frank Brady, Toshihiro Takahashi, Akira Ujiie

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

[¹⁸F]fluoride was produced via the ¹⁸O(p,n)¹⁸F reaction with a circulating 20% enriched [¹⁸O]water target. Parameters affecting the production yield of [¹⁸F]fluoride such as beam current, beam profile, irradiation time, target thickness, circulation rate, and window material were investigated and optimized. With a 20 μA irradiation of 2.5 mL [¹⁸O]water circulated at a flow rate of over 35 mL/min, a [¹⁸F]fluoride yield of more than 70% was obtained when the beam was defocussed and wobbled to get a uniform beam profile. In addition, radiolytically produced gases were recombined using a Pd catalyst into the target.

Original language	English
Pages (from-to)	979-984
Number of pages	6
Journal	International Journal of Radiation Applications and Instrumentation. Part
Volume	38
Issue number	11
DOIs	https://doi.org/10.1016/0883-2889(87)90272-3
Publication status	Published - 1987
Externally published	Yes

ASJC Scopus subject areas

Radiation
Engineering(all)

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title = "[18F]fluoride production with a circulating [18O]water target",

abstract = "[18F]fluoride was produced via the 18O(p,n)18F reaction with a circulating 20% enriched [18O]water target. Parameters affecting the production yield of [18F]fluoride such as beam current, beam profile, irradiation time, target thickness, circulation rate, and window material were investigated and optimized. With a 20 μA irradiation of 2.5 mL [18O]water circulated at a flow rate of over 35 mL/min, a [18F]fluoride yield of more than 70% was obtained when the beam was defocussed and wobbled to get a uniform beam profile. In addition, radiolytically produced gases were recombined using a Pd catalyst into the target.",

author = "Ren Iwata and Tatsuo Ido and Frank Brady and Toshihiro Takahashi and Akira Ujiie",

note = "Funding Information: Acknowledgements-The authors would like to thank the cyclotronm achineg roup for carryingo ut the irradiations and Mr. M. Monma for his technicala ssistanceR. . Iwata is grateful to Professor M. Fujioka for his valuables ug-gestiona boutt argetc ooling and Dr B. W. Wielando f CT1 Corp. for stimulatingd iscussionsF. . Bradyi s gratefutl o the Japan Societyf or Promotion of Science/RoyaSl ocietyf or the award of a PostdoctoralF ellowship. Funding Information: *On leave of absence from Medical Research Council Cyclotron Unit, Hammersmith Hospital, London, 1J.K.",

year = "1987",

doi = "10.1016/0883-2889(87)90272-3",

language = "English",

volume = "38",

pages = "979--984",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier Limited",

number = "11",

}

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T1 - [18F]fluoride production with a circulating [18O]water target

AU - Iwata, Ren

AU - Ido, Tatsuo

AU - Brady, Frank

AU - Takahashi, Toshihiro

AU - Ujiie, Akira

N1 - Funding Information: Acknowledgements-The authors would like to thank the cyclotronm achineg roup for carryingo ut the irradiations and Mr. M. Monma for his technicala ssistanceR. . Iwata is grateful to Professor M. Fujioka for his valuables ug-gestiona boutt argetc ooling and Dr B. W. Wielando f CT1 Corp. for stimulatingd iscussionsF. . Bradyi s gratefutl o the Japan Societyf or Promotion of Science/RoyaSl ocietyf or the award of a PostdoctoralF ellowship. Funding Information: *On leave of absence from Medical Research Council Cyclotron Unit, Hammersmith Hospital, London, 1J.K.

PY - 1987

Y1 - 1987

N2 - [18F]fluoride was produced via the 18O(p,n)18F reaction with a circulating 20% enriched [18O]water target. Parameters affecting the production yield of [18F]fluoride such as beam current, beam profile, irradiation time, target thickness, circulation rate, and window material were investigated and optimized. With a 20 μA irradiation of 2.5 mL [18O]water circulated at a flow rate of over 35 mL/min, a [18F]fluoride yield of more than 70% was obtained when the beam was defocussed and wobbled to get a uniform beam profile. In addition, radiolytically produced gases were recombined using a Pd catalyst into the target.

AB - [18F]fluoride was produced via the 18O(p,n)18F reaction with a circulating 20% enriched [18O]water target. Parameters affecting the production yield of [18F]fluoride such as beam current, beam profile, irradiation time, target thickness, circulation rate, and window material were investigated and optimized. With a 20 μA irradiation of 2.5 mL [18O]water circulated at a flow rate of over 35 mL/min, a [18F]fluoride yield of more than 70% was obtained when the beam was defocussed and wobbled to get a uniform beam profile. In addition, radiolytically produced gases were recombined using a Pd catalyst into the target.

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VL - 38

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JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

IS - 11

ER -

[¹⁸F]fluoride production with a circulating [¹⁸O]water target

Abstract

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