Supercritical hydrothermal synthesis of organic-inorganic hybrid nanoparticles

Mousavand Tahereh, Seiichi Takami, Satoshi Ohara, Mitsuo Umetsu, Tadafumi Adschiri

Research output: Contribution to journalConference articlepeer-review


We have developed supercritical hydrothermal synthesis method of nanoparticles. In the method, metal salt aqueous solution is mixed with high temperature water to rapidly increase the temperature of the metal salt solution and thus reduce the reactions and crystallizations during the heating up period. By using this method, we succeeded in the continuous and rapid production of nanocrystals. In this paper, we propose a new method to synthesize organic-inorganic fused materials based on the methods of supercritical hydrothermal synthesis. By introducing organic materials in a reaction atmosphere of supercritical hydrothermal synthesis, nanoparticles whose surface was modified with organic materials were synthesized. In supercritical state, water and organic materials form a homogeneous phase, which provides an excellent reaction atmosphere for the organic modification of nanoparticles. Modification with bio-materials including amino acids was also possible. By changing organic modifiers, particle morphology and crystal structure were changed. This organic surface modification provides a various unique characteristics for the nanoparticles: Dispersion of nanoparticles in aqueous solutions, organic solvents or in liquid polymers can be controlled by selecting hydrophilic or hydrophobic modifiers. Polymer-like materials can be formed for the amino acid modified nanoparticles probably by the self-assembly of amino acid.

Original languageEnglish
Article number23
Pages (from-to)85-91
Number of pages7
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Publication statusPublished - 2005
EventNanobiophotonics and Biomedical Applications II - San Jose, CA, United States
Duration: 2005 Jan 242005 Jan 27


  • Hydrothermal synthesis
  • Nanoparticles
  • Organic inorganic hybrid
  • Supercritical
  • Surface modification


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