Suppression by glucocorticoid of the immunoreactivity of corticotropin-releasing factor and vasopressin in the paraventricular nucleus of rat hypothalamus

Keiichi Itoi; Toraichi Mouri; Kazuhiro Takahashi; Osamu Murakami; Yutaka Imai; Shuichi Sasaki; Kaoru Yoshinaga; Nobuaki Sasano

doi:10.1016/0304-3940(87)90250-3

Suppression by glucocorticoid of the immunoreactivity of corticotropin-releasing factor and vasopressin in the paraventricular nucleus of rat hypothalamus

Keiichi Itoi, Toraichi Mouri, Kazuhiro Takahashi, Osamu Murakami, Yutaka Imai, Shuichi Sasaki, Kaoru Yoshinaga, Nobuaki Sasano

MED - Health Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The effect of glucocorticoid on the production of corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus of the hypothalamus (PVH) was examined immunocytochemically. Intraperitoneal administration of dexamethasone sulfate in a dose of 0.1 mg/day suppressed the immunoreactivity of CRF and vasopressin in the medial parvocellular divisions of the PVH of the rat subsequent to bilateral adrenalectomy. In the magnocellular divisions, suppression of vasopressin-immunoreactivity was not observed. These results suggest that the vasopressin in the medial parvocellular divisions plays a distinct role from that in the magnocellular divisions, the former having functional significance in the hypothalamo-hypophysio-adrenal axis.

Original language	English
Pages (from-to)	231-236
Number of pages	6
Journal	Neuroscience Letters
Volume	73
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(87)90250-3
Publication status	Published - 1987 Jan 27

Keywords

Corticotropin-releasing factor
Glucocorticoid
Hypothalamus
Immunocytochemistry
Paraventricular nucleus
Rat brain
Vasopressin

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10.1016/0304-3940(87)90250-3

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title = "Suppression by glucocorticoid of the immunoreactivity of corticotropin-releasing factor and vasopressin in the paraventricular nucleus of rat hypothalamus",

abstract = "The effect of glucocorticoid on the production of corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus of the hypothalamus (PVH) was examined immunocytochemically. Intraperitoneal administration of dexamethasone sulfate in a dose of 0.1 mg/day suppressed the immunoreactivity of CRF and vasopressin in the medial parvocellular divisions of the PVH of the rat subsequent to bilateral adrenalectomy. In the magnocellular divisions, suppression of vasopressin-immunoreactivity was not observed. These results suggest that the vasopressin in the medial parvocellular divisions plays a distinct role from that in the magnocellular divisions, the former having functional significance in the hypothalamo-hypophysio-adrenal axis.",

keywords = "Corticotropin-releasing factor, Glucocorticoid, Hypothalamus, Immunocytochemistry, Paraventricular nucleus, Rat brain, Vasopressin",

author = "Keiichi Itoi and Toraichi Mouri and Kazuhiro Takahashi and Osamu Murakami and Yutaka Imai and Shuichi Sasaki and Kaoru Yoshinaga and Nobuaki Sasano",

note = "Funding Information: We thank Dr. Y. Itoi for the printing of the photomicrographs in Fig. 1. This study was supported in part by the Research Grant for the Intractable Diseases from the Ministry of Health and Welfare of Japan.",

year = "1987",

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doi = "10.1016/0304-3940(87)90250-3",

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AU - Itoi, Keiichi

AU - Mouri, Toraichi

AU - Takahashi, Kazuhiro

AU - Murakami, Osamu

AU - Imai, Yutaka

AU - Sasaki, Shuichi

AU - Yoshinaga, Kaoru

AU - Sasano, Nobuaki

N1 - Funding Information: We thank Dr. Y. Itoi for the printing of the photomicrographs in Fig. 1. This study was supported in part by the Research Grant for the Intractable Diseases from the Ministry of Health and Welfare of Japan.

PY - 1987/1/27

Y1 - 1987/1/27

N2 - The effect of glucocorticoid on the production of corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus of the hypothalamus (PVH) was examined immunocytochemically. Intraperitoneal administration of dexamethasone sulfate in a dose of 0.1 mg/day suppressed the immunoreactivity of CRF and vasopressin in the medial parvocellular divisions of the PVH of the rat subsequent to bilateral adrenalectomy. In the magnocellular divisions, suppression of vasopressin-immunoreactivity was not observed. These results suggest that the vasopressin in the medial parvocellular divisions plays a distinct role from that in the magnocellular divisions, the former having functional significance in the hypothalamo-hypophysio-adrenal axis.

AB - The effect of glucocorticoid on the production of corticotropin-releasing factor (CRF) and vasopressin in the paraventricular nucleus of the hypothalamus (PVH) was examined immunocytochemically. Intraperitoneal administration of dexamethasone sulfate in a dose of 0.1 mg/day suppressed the immunoreactivity of CRF and vasopressin in the medial parvocellular divisions of the PVH of the rat subsequent to bilateral adrenalectomy. In the magnocellular divisions, suppression of vasopressin-immunoreactivity was not observed. These results suggest that the vasopressin in the medial parvocellular divisions plays a distinct role from that in the magnocellular divisions, the former having functional significance in the hypothalamo-hypophysio-adrenal axis.

KW - Corticotropin-releasing factor

KW - Glucocorticoid

KW - Hypothalamus

KW - Immunocytochemistry

KW - Paraventricular nucleus

KW - Rat brain

KW - Vasopressin

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ER -

Suppression by glucocorticoid of the immunoreactivity of corticotropin-releasing factor and vasopressin in the paraventricular nucleus of rat hypothalamus

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Keywords

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