TY - JOUR
T1 - Surface-assisted laser desorption ionization mass spectrometry (SALDI-MS) of low-molecular-weight medicines and toxic materials using commercial TiO2 nanoparticles
AU - Yonezawa, Tetsu
AU - Asano, Takashi
AU - Matsubara, Masaki
N1 - Funding Information:
This work was partially supported by the Hokkaido University (to TY) and Grant-in-Aid for Scientific Research (A) from JSPS, Japan (to TY No. 24241041).
Publisher Copyright:
© 2016 The Chemical Society of Japan.
PY - 2016
Y1 - 2016
N2 - The ability of surface-assisted laser desorption/ionization mass spectroscopy (SALDI-MS) of low-molecular-weight compounds using six types of commercially available TiO2 nanoparticles (NPs) was examined. In all cases, TiO2 NPs gave strong Na+-adduct sample ion peaks. Some chemicals, which rarely show proton-adduct sample ion peaks by MALDI-MS, such as aspirin and barbital, could be easily detected by using TiO2 NPs. The key factors determining the SALDI ability of TiO2 NPs are their purity, ratio of rutile, and particle size.
AB - The ability of surface-assisted laser desorption/ionization mass spectroscopy (SALDI-MS) of low-molecular-weight compounds using six types of commercially available TiO2 nanoparticles (NPs) was examined. In all cases, TiO2 NPs gave strong Na+-adduct sample ion peaks. Some chemicals, which rarely show proton-adduct sample ion peaks by MALDI-MS, such as aspirin and barbital, could be easily detected by using TiO2 NPs. The key factors determining the SALDI ability of TiO2 NPs are their purity, ratio of rutile, and particle size.
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U2 - 10.1246/bcsj.20150337
DO - 10.1246/bcsj.20150337
M3 - Article
AN - SCOPUS:84961777291
SN - 0009-2673
VL - 89
SP - 346
EP - 353
JO - Bulletin of the Chemical Society of Japan
JF - Bulletin of the Chemical Society of Japan
IS - 3
ER -