Surface grafting of artificial joints with a biocompatible polymer for preventing periprosthetic osteolysis

Toru Moro, Yoshio Takatori, Kazuhiko Ishihara, Tomohiro Konno, Yorinobu Takigawa, Tomiharu Matsushita, Ung I.L. Chung, Kozo Nakamura, Hiroshi Kawaguchi

Research output: Contribution to journalArticlepeer-review

527 Citations (Scopus)


Periprosthetic osteolysis - bone loss in the vicinity of a prosthesis - is the most serious problem limiting the longevity of artificial joints. It is caused by bone-resorptive responses to wear particles originating from the articulating surface. This study investigated the effects of graft polymerization of our original biocompatible phospholipid polymer 2-methacryloyloxyethyl phosphorylcholine (MPC) onto the polyethylene surface. Mechanical studies using a hip-joint simulator revealed that the MPC grafting markedly decreased the friction and the amount of wear. Osteoclastic bone resorption induced by subperiosteal injection of particles onto mouse calvariae was abolished by the MPC grafting on particles. MPC-grafted particles were shown to be biologically inert by culture systems with respect to phagocytosis and resorptive cytokine secretion by macrophages, subsequent expression of receptor activator of NF-kB ligand in osteoblasts, and osteoclastogenesis from bone marrow cells. From the mechanical and biological advantages, we believe that our approach will make a major improvement in artificial joints by preventing periprosthetic osteolysis.

Original languageEnglish
Pages (from-to)829-836
Number of pages8
JournalNature Materials
Issue number11
Publication statusPublished - 2004 Nov


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