Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity

Ayano Takeuchi; Makihito Hori; Shinichi Sato; Hyun Seung Ban; Takahiro Kuchimaru; Shinae Kizaka-Kondoh; Takao Yamori; Hiroyuki Nakamura

doi:10.1039/c2md20134h

Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity

Ayano Takeuchi, Makihito Hori, Shinichi Sato, Hyun Seung Ban, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Takao Yamori, Hiroyuki Nakamura

FRIS - Core Interdisciplinary Research Section

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

New YC-1 derivatives were synthesized and evaluated with HIF-1 transcriptional activity, and a potent derivative shows activity in vivo. Furthermore, for the mechanistic study of the YC-1 derivative, we evaluate the antiproliferative activity against 39 human cancer cell lines and the localization of active probes in cells.

Original language	English
Pages (from-to)	1455-1461
Number of pages	7
Journal	MedChemComm
Volume	3
Issue number	11
DOIs	https://doi.org/10.1039/c2md20134h
Publication status	Published - 2012 Nov

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title = "Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity",

abstract = "New YC-1 derivatives were synthesized and evaluated with HIF-1 transcriptional activity, and a potent derivative shows activity in vivo. Furthermore, for the mechanistic study of the YC-1 derivative, we evaluate the antiproliferative activity against 39 human cancer cell lines and the localization of active probes in cells.",

author = "Ayano Takeuchi and Makihito Hori and Shinichi Sato and Ban, {Hyun Seung} and Takahiro Kuchimaru and Shinae Kizaka-Kondoh and Takao Yamori and Hiroyuki Nakamura",

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AU - Takeuchi, Ayano

AU - Hori, Makihito

AU - Sato, Shinichi

AU - Ban, Hyun Seung

AU - Kuchimaru, Takahiro

AU - Kizaka-Kondoh, Shinae

AU - Yamori, Takao

AU - Nakamura, Hiroyuki

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AB - New YC-1 derivatives were synthesized and evaluated with HIF-1 transcriptional activity, and a potent derivative shows activity in vivo. Furthermore, for the mechanistic study of the YC-1 derivative, we evaluate the antiproliferative activity against 39 human cancer cell lines and the localization of active probes in cells.

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Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity

Abstract

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