Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues

Qian Cheng, Hiromasa Kiyota, Marina Yamaguchi, Tohru Horiguchi, Takayuki Oritani

    Research output: Contribution to journalArticlepeer-review

    32 Citations (Scopus)

    Abstract

    Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular SN2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.

    Original languageEnglish
    Pages (from-to)1075-1077
    Number of pages3
    JournalBioorganic and Medicinal Chemistry Letters
    Volume13
    Issue number6
    DOIs
    Publication statusPublished - 2003 Mar 24

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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