TY - JOUR
T1 - Synthesis and biological evaluation of gambierol analogues
AU - Fuwa, Haruhiko
AU - Kainuma, Noriko
AU - Satake, Masayuki
AU - Sasaki, Makoto
N1 - Funding Information:
We are very grateful to Professor Kazuo Tachibana, The University of Tokyo, for his helpful discussion. This work was financially supported by CREST, Japan Science and Technology Corporation (JST) and Suntory Institute for Bioorganic Research (SUNBOR).
PY - 2003/8/4
Y1 - 2003/8/4
N2 - Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure-activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity.
AB - Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure-activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity.
UR - http://www.scopus.com/inward/record.url?scp=0038648266&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038648266&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(03)00467-0
DO - 10.1016/S0960-894X(03)00467-0
M3 - Article
C2 - 12852956
AN - SCOPUS:0038648266
SN - 0960-894X
VL - 13
SP - 2519
EP - 2522
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 15
ER -
