Synthesis and biological evaluation of gambierol analogues

Haruhiko Fuwa, Noriko Kainuma, Masayuki Satake, Makoto Sasaki

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)


Gambierol is a polycyclic ether toxin, isolated as a toxic constituent from the marine dinoflagellate Gambierdiscus toxicus. We describe here the synthesis and biological evaluation of structural analogues of gambierol. The present preliminary structure-activity relationship studies clearly indicate that the H ring functionality and the unsaturated side chain of gambierol are crucial for its potent toxicity.

Original languageEnglish
Pages (from-to)2519-2522
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number15
Publication statusPublished - 2003 Aug 4


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