Synthesis and optical resolution of an anti-O,O′-dialkylated calix[4]arene

Fumitaka Narumi, Waka Yamabuki, Tetsutaro Hattori, Hiroshi Kameyama, Sotaro Miyano

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


Proximally O,O′-disiloxane-bridged calix[4]arene (1) was treated with benzyl bromide in the presence of Cs2CO3 to afford, after desilylation, anti-O,O′-dibenzylcalix[4]arene (4a) in 90% yield. Chromatographic separation of its diastereomeric (S)-2-methoxy-2-(1-naphthyl)propionic esters allowed the first optical resolution of this kind of dialkylated calix[4]arenes.

Original languageEnglish
Pages (from-to)320-321
Number of pages2
JournalChemistry Letters
Issue number4
Publication statusPublished - 2003 Apr 5


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