Synthesis and solution properties of hydrophobically modified cluster dextrin

Yavoi Ozawa; Nobuyuki Morimoto; Shin Ichi Kitamura; Kazunari Akiyoshi

Synthesis and solution properties of hydrophobically modified cluster dextrin

Yavoi Ozawa, Nobuyuki Morimoto, Shin Ichi Kitamura, Kazunari Akiyoshi

Research output: Contribution to conference › Paper › peer-review

Abstract

We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5 by ¹H-NMR. Solution properties of CH-CDex in water were investigated by SEC-MALS and DLS. CH-CDex formed self-associates consisting of 3-4 CH-CDex macromolecules, and the particle size (diameter) was 40 nm by DLS.

Original language	English
Number of pages	1
Publication status	Published - 2005 Dec 1
Externally published	Yes
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: 2005 Sept 20 → 2005 Sept 22

Other

Other	54th SPSJ Symposium on Macromolecules
Country/Territory	Japan
City	Yamagata
Period	05/9/20 → 05/9/22

Keywords

Cluster dextrin /
Hydrophobically modified polysaccharides
Nanogels
Self-assembly

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Synthesis and solution properties of hydrophobically modified cluster dextrin",

abstract = "We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5 by 1H-NMR. Solution properties of CH-CDex in water were investigated by SEC-MALS and DLS. CH-CDex formed self-associates consisting of 3-4 CH-CDex macromolecules, and the particle size (diameter) was 40 nm by DLS.",

keywords = "Cluster dextrin /, Hydrophobically modified polysaccharides, Nanogels, Self-assembly",

author = "Yavoi Ozawa and Nobuyuki Morimoto and Kitamura, {Shin Ichi} and Kazunari Akiyoshi",

year = "2005",

month = dec,

day = "1",

language = "English",

note = "54th SPSJ Symposium on Macromolecules ; Conference date: 20-09-2005 Through 22-09-2005",

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TY - CONF

T1 - Synthesis and solution properties of hydrophobically modified cluster dextrin

AU - Ozawa, Yavoi

AU - Morimoto, Nobuyuki

AU - Kitamura, Shin Ichi

AU - Akiyoshi, Kazunari

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5 by 1H-NMR. Solution properties of CH-CDex in water were investigated by SEC-MALS and DLS. CH-CDex formed self-associates consisting of 3-4 CH-CDex macromolecules, and the particle size (diameter) was 40 nm by DLS.

AB - We developed a novel artificial chaperone and drug delivery system using cholesteryl group-bearing pullulan (CHP) nanogels. In this report, we synthesized cholesteryl group-bearing cluster dextrin which is highly branched dextrin with narrow molecular weight distribution (CH-CDex). The number of cholesteryl groups per 100 glucose units were 1.5 by 1H-NMR. Solution properties of CH-CDex in water were investigated by SEC-MALS and DLS. CH-CDex formed self-associates consisting of 3-4 CH-CDex macromolecules, and the particle size (diameter) was 40 nm by DLS.

KW - Cluster dextrin /

KW - Hydrophobically modified polysaccharides

KW - Nanogels

KW - Self-assembly

UR - http://www.scopus.com/inward/record.url?scp=33645650688&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645650688&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645650688

T2 - 54th SPSJ Symposium on Macromolecules

Y2 - 20 September 2005 through 22 September 2005

ER -

Synthesis and solution properties of hydrophobically modified cluster dextrin

Abstract

Other

Keywords

ASJC Scopus subject areas

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