A fluorine‐18 labelled analog of arachidonic acid, 20‐[18F]fluoroarachidonic acid, was prepared for evaluation as a potential phospholipid metabolic agent. The radiosynthesis was accomplished by [18F]fluoride ion displacement on the tosylate precursor followed by basic hydrolysis of the ester group, in isolated radiochemical yield (not decay corrected) of 10 % in overall synthesis time (including HPLC purification) of 110 min.
|Number of pages||7|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|Publication status||Published - 1994 Dec|
- 20‐[F]fluoroarachidonic acid
- [F]fluoride ion
- tosylate displacement