Synthesis of a bisubstrate-type inhibitor of N- acetylglucosaminyltransferases

Shinya Hanashima, Shino Manabe, Kei Ichiro Inamori, Naoyuki Taniguchi, Yukishige Ito

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)


Transfer interference: Synthesis of the bisubstrate-type N-acetylglucosaminyltransferase (GnT) inhibitor 1 was achieved by a polymer-resin hybrid capture-release strategy for the construction of the acceptor component. One-pot ligation in aqueous media produced the coupling product, and subsequent construction of a diphosphate linkage led to 1. Inhibitory activities toward GnT-V and GnT-IX were evaluated and revealed the potency of 1 toward the latter enzyme.

Original languageEnglish
Pages (from-to)5674-5677
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number42
Publication statusPublished - 2004 Oct 25


  • Bisubstrates
  • Glycoproteins
  • Inhibitors
  • Solid-phase synthesis
  • Transferases


Dive into the research topics of 'Synthesis of a bisubstrate-type inhibitor of N- acetylglucosaminyltransferases'. Together they form a unique fingerprint.

Cite this