Synthesis of bacilosarcins B and C

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    10 Citations (Scopus)


    The first synthesis of bacilosarcin C, a member of amicoumacin family of natural product isolated from the culture broth of a marine bacterium, has been achieved in 2 steps by diastereoselective reductive amination of amicoumacin C with 2,3-butanedione followed by hydrolysis of the resulting N-alkylated lactone intermediate. Ammonolysis of the intermediate, on the other hand, led to an improved synthesis of bacilosarcin B, an amide congener of bacilosarcin C.

    Original languageEnglish
    Pages (from-to)4997-4999
    Number of pages3
    JournalTetrahedron Letters
    Issue number45
    Publication statusPublished - 2016


    • Amicoumacin
    • Bacilosarcin
    • Isocoumarin
    • Reductive amination
    • Total synthesis

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry


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