Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

Hiroshi Tanaka; Yoshikazu Tanaka; Masafumi Minoshima; Sho Yamaguchi; Shinichiro Fuse; Takayuki Doi; Susumu Kawauchi; Hiroshi Sugiyama; Takashi Takahashi

doi:10.1039/c0cc01286f

Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

Hiroshi Tanaka, Yoshikazu Tanaka, Masafumi Minoshima, Sho Yamaguchi, Shinichiro Fuse, Takayuki Doi, Susumu Kawauchi, Hiroshi Sugiyama, Takashi Takahashi

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.

Original language	English
Pages (from-to)	5942-5944
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	32
DOIs	https://doi.org/10.1039/c0cc01286f
Publication status	Published - 2010 Aug 28

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abstract = "The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.",

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T1 - Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

AU - Tanaka, Hiroshi

AU - Tanaka, Yoshikazu

AU - Minoshima, Masafumi

AU - Yamaguchi, Sho

AU - Fuse, Shinichiro

AU - Doi, Takayuki

AU - Kawauchi, Susumu

AU - Sugiyama, Hiroshi

AU - Takahashi, Takashi

PY - 2010/8/28

Y1 - 2010/8/28

N2 - The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.

AB - The synthesis of a bicyclic enediyne capable of photosensitive triggering and conjugated to a pyrrole-imidazole polyamide is described. Using UV irradiation, this hybrid molecule is shown to exhibit 100-fold stronger potency for DNA cleavage, in an in vitro assay, as compared to the enediyne without the DNA-localizing pyrrole-imidazole.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Synthesis of bicyclic enediynes that possess a photosensitive triggering device and exhibit strong DNA cleaving activity

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