Synthesis of bioactive HEMA-MPS-CaCl2 hybrid gels: Effects of catalysts in the sol-gel processing on mechanical properties and in vitro hydroxyapatite formation in a simulated body fluid

Tomohiro Uchino; Chikara Ohtsuki; Masanobu Kamitakahara; Toshiki Miyazaki; Satoshi Hayakawa; Akiyoshi Osaka

doi:10.1177/0885328208094262

Synthesis of bioactive HEMA-MPS-CaCl₂ hybrid gels: Effects of catalysts in the sol-gel processing on mechanical properties and in vitro hydroxyapatite formation in a simulated body fluid

Tomohiro Uchino, Chikara Ohtsuki, Masanobu Kamitakahara, Toshiki Miyazaki, Satoshi Hayakawa, Akiyoshi Osaka

ENV - Environmental Studies for Advanced Society

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We investigated synthetic conditions for the fabrication of bioactive hybrid gels from monomers of 2-hydroxyethylmethacrylate (HEMA) and 3-methacryloxypropyltrimethoxysilane (MPS) in combination with CaCl₂, at a starting molar ratio of HEMA: MPS : CaCl₂ of 9 : 1 : 1. Hydroxyapatite formation, essential to show bone bonding, was observed on the HEMA- MPS-CaCl₂ hybrid gels with the added catalysts NH₂ or HCl with a molar ratio to MPS of 0.1, but not on the hybrid gel with HCl at a molar ratio to MPS of 1. The mechanical properties of the gels were dependent on the catalysts, which may affect the microstructures that develop during sol-gel processing.

Original language	English
Pages (from-to)	519-532
Number of pages	14
Journal	Journal of Biomaterials Applications
Volume	23
Issue number	6
DOIs	https://doi.org/10.1177/0885328208094262
Publication status	Published - 2009

Keywords

Bone bonding
Hydroxyapatite
Mechanical property
Simulated body fluid
Sol-gel processing

ASJC Scopus subject areas

Biomaterials
Biomedical Engineering

Access to Document

10.1177/0885328208094262

Cite this

Uchino, T., Ohtsuki, C., Kamitakahara, M., Miyazaki, T., Hayakawa, S., & Osaka, A. (2009). Synthesis of bioactive HEMA-MPS-CaCl₂ hybrid gels: Effects of catalysts in the sol-gel processing on mechanical properties and in vitro hydroxyapatite formation in a simulated body fluid. Journal of Biomaterials Applications, 23(6), 519-532. https://doi.org/10.1177/0885328208094262

Synthesis of bioactive HEMA-MPS-CaCl₂ hybrid gels: Effects of catalysts in the sol-gel processing on mechanical properties and in vitro hydroxyapatite formation in a simulated body fluid. / Uchino, Tomohiro; Ohtsuki, Chikara; Kamitakahara, Masanobu et al.
In: Journal of Biomaterials Applications, Vol. 23, No. 6, 2009, p. 519-532.

Research output: Contribution to journal › Article › peer-review

Uchino, T, Ohtsuki, C, Kamitakahara, M, Miyazaki, T, Hayakawa, S & Osaka, A 2009, 'Synthesis of bioactive HEMA-MPS-CaCl₂ hybrid gels: Effects of catalysts in the sol-gel processing on mechanical properties and in vitro hydroxyapatite formation in a simulated body fluid', Journal of Biomaterials Applications, vol. 23, no. 6, pp. 519-532. https://doi.org/10.1177/0885328208094262

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abstract = "We investigated synthetic conditions for the fabrication of bioactive hybrid gels from monomers of 2-hydroxyethylmethacrylate (HEMA) and 3-methacryloxypropyltrimethoxysilane (MPS) in combination with CaCl2, at a starting molar ratio of HEMA: MPS : CaCl2 of 9 : 1 : 1. Hydroxyapatite formation, essential to show bone bonding, was observed on the HEMA- MPS-CaCl2 hybrid gels with the added catalysts NH2 or HCl with a molar ratio to MPS of 0.1, but not on the hybrid gel with HCl at a molar ratio to MPS of 1. The mechanical properties of the gels were dependent on the catalysts, which may affect the microstructures that develop during sol-gel processing.",

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