Synthesis of bone formation deriving biosilanes

Norio Yoshino; Kaori Nakajima; Keisuke Nakamura; Yukishige Kondo; Katsura Ohashi; Tomotaro Nihei; Masahiro Saito; Toshio Teranaka

doi:10.1016/j.colsurfb.2008.05.009

Synthesis of bone formation deriving biosilanes

Norio Yoshino, Kaori Nakajima, Keisuke Nakamura, Yukishige Kondo, Katsura Ohashi, Tomotaro Nihei, Masahiro Saito, Toshio Teranaka

DEN - Dental Sciences

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Six silane coupling agents having amide group (biosilanes) were synthesized with the aim to construct the material surface that allows cells to be compatible with it without their destruction. These agents were expected to make a soft landing to cytoplasm through the hydrogen bonding between their amide groups and cells. Evaluations of cell affinity using glass substrates modified with the synthesized biosilanes revealed that many cells remain on the modified glass plate. In addition, the implantation into the body of immunodeficient mouse of a composite material composed of porous hydroxyapatite and osteoblast showed the formation of a bone-like structure.

Original language	English
Pages (from-to)	71-76
Number of pages	6
Journal	Colloids and Surfaces B: Biointerfaces
Volume	66
Issue number	1
DOIs	https://doi.org/10.1016/j.colsurfb.2008.05.009
Publication status	Published - 2008 Oct 1

Keywords

Biosilane
Bone formation
Cell affinity
Silane coupling agent having amide group
Surface modification

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10.1016/j.colsurfb.2008.05.009

Cite this

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title = "Synthesis of bone formation deriving biosilanes",

abstract = "Six silane coupling agents having amide group (biosilanes) were synthesized with the aim to construct the material surface that allows cells to be compatible with it without their destruction. These agents were expected to make a soft landing to cytoplasm through the hydrogen bonding between their amide groups and cells. Evaluations of cell affinity using glass substrates modified with the synthesized biosilanes revealed that many cells remain on the modified glass plate. In addition, the implantation into the body of immunodeficient mouse of a composite material composed of porous hydroxyapatite and osteoblast showed the formation of a bone-like structure.",

keywords = "Biosilane, Bone formation, Cell affinity, Silane coupling agent having amide group, Surface modification",

author = "Norio Yoshino and Kaori Nakajima and Keisuke Nakamura and Yukishige Kondo and Katsura Ohashi and Tomotaro Nihei and Masahiro Saito and Toshio Teranaka",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (B) (No. 19390487) from the Ministry of Education, Science, Sports, and Culture of Japan.",

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T1 - Synthesis of bone formation deriving biosilanes

AU - Yoshino, Norio

AU - Nakajima, Kaori

AU - Nakamura, Keisuke

AU - Kondo, Yukishige

AU - Ohashi, Katsura

AU - Nihei, Tomotaro

AU - Saito, Masahiro

AU - Teranaka, Toshio

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research (B) (No. 19390487) from the Ministry of Education, Science, Sports, and Culture of Japan.

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Six silane coupling agents having amide group (biosilanes) were synthesized with the aim to construct the material surface that allows cells to be compatible with it without their destruction. These agents were expected to make a soft landing to cytoplasm through the hydrogen bonding between their amide groups and cells. Evaluations of cell affinity using glass substrates modified with the synthesized biosilanes revealed that many cells remain on the modified glass plate. In addition, the implantation into the body of immunodeficient mouse of a composite material composed of porous hydroxyapatite and osteoblast showed the formation of a bone-like structure.

AB - Six silane coupling agents having amide group (biosilanes) were synthesized with the aim to construct the material surface that allows cells to be compatible with it without their destruction. These agents were expected to make a soft landing to cytoplasm through the hydrogen bonding between their amide groups and cells. Evaluations of cell affinity using glass substrates modified with the synthesized biosilanes revealed that many cells remain on the modified glass plate. In addition, the implantation into the body of immunodeficient mouse of a composite material composed of porous hydroxyapatite and osteoblast showed the formation of a bone-like structure.

KW - Biosilane

KW - Bone formation

KW - Cell affinity

KW - Silane coupling agent having amide group

KW - Surface modification

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JO - Colloids and Surfaces B: Biointerfaces

JF - Colloids and Surfaces B: Biointerfaces

IS - 1

ER -

Synthesis of bone formation deriving biosilanes

Abstract

Keywords

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