Synthesis of bone formation deriving biosilanes

Norio Yoshino, Kaori Nakajima, Keisuke Nakamura, Yukishige Kondo, Katsura Ohashi, Tomotaro Nihei, Masahiro Saito, Toshio Teranaka

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Six silane coupling agents having amide group (biosilanes) were synthesized with the aim to construct the material surface that allows cells to be compatible with it without their destruction. These agents were expected to make a soft landing to cytoplasm through the hydrogen bonding between their amide groups and cells. Evaluations of cell affinity using glass substrates modified with the synthesized biosilanes revealed that many cells remain on the modified glass plate. In addition, the implantation into the body of immunodeficient mouse of a composite material composed of porous hydroxyapatite and osteoblast showed the formation of a bone-like structure.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalColloids and Surfaces B: Biointerfaces
Issue number1
Publication statusPublished - 2008 Oct 1


  • Biosilane
  • Bone formation
  • Cell affinity
  • Silane coupling agent having amide group
  • Surface modification


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