Synthesis of Both Enantiomers of Altholactone, Isoaltholactone and 5-Hydroxygoniothalamin from Tri-O-acetyl-D-glucal, and Their Biological Activities

Akira Hiratate, Hiromasa Kiyota, Toshiro Noshita, Ryo Takeuchi, Takayuki Oritani

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    Both enantiomers of altholactone, isoaltholactone and 5-hydroxygoniothalamin were synthesized from tri-O-acetyl-D-glucal, and biological activities of altholactones were examined. For brine shrimp, the configuration of 3-hydroxy group at convex site was important for lethal activity, while (2S,3S)-configuration was inhibitory to lettuce germination.

    Original languageEnglish
    Pages (from-to)366-370
    Number of pages5
    JournalJournal of Pesticide Science
    Volume26
    Issue number4
    DOIs
    Publication statusPublished - 2001

    Keywords

    • 5-hydroxygoniothalamin
    • altholactone
    • isoaltholactone
    • total synthesis
    • tri-O-acetyl-D-glucal

    ASJC Scopus subject areas

    • Insect Science
    • Health, Toxicology and Mutagenesis

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