Synthesis of (-)-Chamobtusin A from (+)-Dehydroabietylamine

Naoki Mori, Kazuma Kuzuya, Hidenori Watanabe

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Chamobtusin A, a unique diterpene alkaloid isolated from Chamaecyparis obtusa cv. tetragon, is considered to be biosynthesized from an abietane diterpenoid. On the basis of this biosynthetic hypothesis, ferruginol (15) was synthesized from (+)-dehydroabietylamine and then biomimetically transformed into (â?)-chamobtusin A in 6 steps (12 steps from (+)-dehydroabietylamine).

Original languageEnglish
Pages (from-to)11866-11870
Number of pages5
JournalJournal of Organic Chemistry
Issue number23
Publication statusPublished - 2016 Dec 2


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