TY - JOUR
T1 - Synthesis of (-)-Chamobtusin A from (+)-Dehydroabietylamine
AU - Mori, Naoki
AU - Kuzuya, Kazuma
AU - Watanabe, Hidenori
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Young Scientists (B) (No. 21780108) to N.M. from the JSPS.
Publisher Copyright:
© 2016 American Chemical Society.
PY - 2016/12/2
Y1 - 2016/12/2
N2 - Chamobtusin A, a unique diterpene alkaloid isolated from Chamaecyparis obtusa cv. tetragon, is considered to be biosynthesized from an abietane diterpenoid. On the basis of this biosynthetic hypothesis, ferruginol (15) was synthesized from (+)-dehydroabietylamine and then biomimetically transformed into (â?)-chamobtusin A in 6 steps (12 steps from (+)-dehydroabietylamine).
AB - Chamobtusin A, a unique diterpene alkaloid isolated from Chamaecyparis obtusa cv. tetragon, is considered to be biosynthesized from an abietane diterpenoid. On the basis of this biosynthetic hypothesis, ferruginol (15) was synthesized from (+)-dehydroabietylamine and then biomimetically transformed into (â?)-chamobtusin A in 6 steps (12 steps from (+)-dehydroabietylamine).
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U2 - 10.1021/acs.joc.6b02328
DO - 10.1021/acs.joc.6b02328
M3 - Article
C2 - 27768308
AN - SCOPUS:85001086215
SN - 0022-3263
VL - 81
SP - 11866
EP - 11870
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 23
ER -