Synthesis of Highly Substituted Pyridines through Copper-Catalyzed Condensation of Oximes and α,β-Unsaturated Imines

Wei Wen Tan, Yew Jin Ong, Naohiko Yoshikai

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)

Abstract

A copper-catalyzed condensation reaction of oxime acetates and α,β-unsaturated ketimines to give pyridine derivatives is reported. The reaction features mild conditions, high functional-group compatibility, and high regioselectivity with respect to unsymmetrical oxime acetates, thus allowing the preparation of a wide range of polysubstituted pyridines, many of which are not readily accessible by conventional condensation methods.

Original languageEnglish
Pages (from-to)8240-8244
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number28
DOIs
Publication statusPublished - 2017 Jul 3

Keywords

  • condensation
  • copper
  • oximes
  • pyridines
  • synthetic methods

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