Synthesis of (±)-lecanindole D

Akiko Asanuma, Masaru Enomoto, Tomohiro Nagasawa, Shigefumi Kuwahara

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)


    The first synthesis of the racemate of lecanindole D, an indole sesquiterpenoid with potent and selective agonist activity toward the progesterone receptor, has been achieved from a known tetracyclic alcohol by using a diastereoselective installation of its tertiary hydroxy group via an epoxide intermediate and a Pd(II)-mediated construction of the indole ring moiety as the key transformations.

    Original languageEnglish
    Pages (from-to)4561-4563
    Number of pages3
    JournalTetrahedron Letters
    Issue number34
    Publication statusPublished - 2013 Aug 21


    • Alkaloid
    • Indole sesquiterpene
    • Lecanindole
    • Progesterone receptor agonist

    ASJC Scopus subject areas

    • Biochemistry
    • Drug Discovery
    • Organic Chemistry


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