Synthesis of lysergic acid methyl ester via the double cyclization strategy

Toshiki Kurokawa; Minetaka Isomura; Hidetoshi Tokuyama; Tohru Fukuyama

doi:10.1055/s-0028-1087948

Synthesis of lysergic acid methyl ester via the double cyclization strategy

Toshiki Kurokawa, Minetaka Isomura, Hidetoshi Tokuyama, Tohru Fukuyama

PHA - Molecular Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

An asymmetric synthesis of (+)-lysergic acid methyl ester was accomplished through construction of the tetracyclic ergoline skeleton by double cyclization consisting of intramolecular aromatic amination and Heck reaction.

Original language	English
Pages (from-to)	775-778
Number of pages	4
Journal	Synlett
Issue number	5
DOIs	https://doi.org/10.1055/s-0028-1087948
Publication status	Published - 2009 Mar

Keywords

Alkaloids
Allylations
Aminations
Heck reaction
Tandem reaction

ASJC Scopus subject areas

Organic Chemistry

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10.1055/s-0028-1087948

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title = "Synthesis of lysergic acid methyl ester via the double cyclization strategy",

abstract = "An asymmetric synthesis of (+)-lysergic acid methyl ester was accomplished through construction of the tetracyclic ergoline skeleton by double cyclization consisting of intramolecular aromatic amination and Heck reaction.",

keywords = "Alkaloids, Allylations, Aminations, Heck reaction, Tandem reaction",

author = "Toshiki Kurokawa and Minetaka Isomura and Hidetoshi Tokuyama and Tohru Fukuyama",

year = "2009",

month = mar,

doi = "10.1055/s-0028-1087948",

language = "English",

pages = "775--778",

journal = "Synlett",

issn = "0936-5214",

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T1 - Synthesis of lysergic acid methyl ester via the double cyclization strategy

AU - Kurokawa, Toshiki

AU - Isomura, Minetaka

AU - Tokuyama, Hidetoshi

AU - Fukuyama, Tohru

PY - 2009/3

Y1 - 2009/3

N2 - An asymmetric synthesis of (+)-lysergic acid methyl ester was accomplished through construction of the tetracyclic ergoline skeleton by double cyclization consisting of intramolecular aromatic amination and Heck reaction.

AB - An asymmetric synthesis of (+)-lysergic acid methyl ester was accomplished through construction of the tetracyclic ergoline skeleton by double cyclization consisting of intramolecular aromatic amination and Heck reaction.

KW - Alkaloids

KW - Allylations

KW - Aminations

KW - Heck reaction

KW - Tandem reaction

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UR - http://www.scopus.com/inward/citedby.url?scp=62349105132&partnerID=8YFLogxK

U2 - 10.1055/s-0028-1087948

DO - 10.1055/s-0028-1087948

M3 - Article

AN - SCOPUS:62349105132

SN - 0936-5214

SP - 775

EP - 778

JO - Synlett

JF - Synlett

IS - 5

ER -

Synthesis of lysergic acid methyl ester via the double cyclization strategy

Abstract

Keywords

ASJC Scopus subject areas

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