Synthesis of monoglucosylated high-mannose-type dodecasaccharide, a putative ligand for molecular chaperone, calnexin, and calreticurin

Ichiro Matsuo; Megumi Wada; Shino Manabe; Yoshiki Yamaguchi; Keisuke Otake; Koichi Kato; Yukishige Ito

doi:10.1021/ja021288q

Synthesis of monoglucosylated high-mannose-type dodecasaccharide, a putative ligand for molecular chaperone, calnexin, and calreticurin

Ichiro Matsuo, Megumi Wada, Shino Manabe, Yoshiki Yamaguchi, Keisuke Otake, Koichi Kato, Yukishige Ito

PHA - Graduate School of Pharmaceutical Sciences (department affiliation only)

Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)

Abstract

Convergent and stereoselective synthetic routes to Man₉GlcNAc₂ (1b), α-Glc₁M₉GlcNAc₂ (2b), and its stereoisomer β-Glc₁M₉GlcNAc₂ (3) were established. Interaction analysis of 2b with CRT was measured by ₁H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.

Original language	English
Pages (from-to)	3402-3403
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	125
Issue number	12
DOIs	https://doi.org/10.1021/ja021288q
Publication status	Published - 2003 Mar 26

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abstract = "Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), α-Glc1M9GlcNAc2 (2b), and its stereoisomer β-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.",

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AU - Matsuo, Ichiro

AU - Wada, Megumi

AU - Manabe, Shino

AU - Yamaguchi, Yoshiki

AU - Otake, Keisuke

AU - Kato, Koichi

AU - Ito, Yukishige

PY - 2003/3/26

Y1 - 2003/3/26

N2 - Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), α-Glc1M9GlcNAc2 (2b), and its stereoisomer β-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.

AB - Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), α-Glc1M9GlcNAc2 (2b), and its stereoisomer β-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.

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JF - Journal of the American Chemical Society

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Synthesis of monoglucosylated high-mannose-type dodecasaccharide, a putative ligand for molecular chaperone, calnexin, and calreticurin

Abstract

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