Synthesis of open-chain C21-C40 fragment of azaspiracid-1

Masato Oikawa; Taizo Iwayama; Makoto Sasaki

doi:10.3987/COM-08-11555

Synthesis of open-chain C21-C40 fragment of azaspiracid-1

Masato Oikawa, Taizo Iwayama, Makoto Sasaki

LIF - Molecular and Chemical Life Science

Tohoku University

Research output: Contribution to journal › Article › peer-review

Abstract

Here, we report a synthesis of a differentially protected, open-chain C21-C40 fragment of azaspiracid-1, corresponding to the lower half EFGHI-ring domain. The synthesis features modular coupling of three advanced intermediates, aiming for diverted analogue synthesis. A new method for construction of E-ring moiety amenable to the diverted synthesis is also reported.

Original language	English
Pages (from-to)	609-615
Number of pages	7
Journal	Heterocycles
Volume	78
Issue number	3
DOIs	https://doi.org/10.3987/COM-08-11555
Publication status	Published - 2009 Mar 1

Keywords

α-Chlorosulfide
Azaspiracid
C21-C40 Fragment
Differential Protection
EFGHI Ring

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10.3987/COM-08-11555

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abstract = "Here, we report a synthesis of a differentially protected, open-chain C21-C40 fragment of azaspiracid-1, corresponding to the lower half EFGHI-ring domain. The synthesis features modular coupling of three advanced intermediates, aiming for diverted analogue synthesis. A new method for construction of E-ring moiety amenable to the diverted synthesis is also reported.",

keywords = "α-Chlorosulfide, Azaspiracid, C21-C40 Fragment, Differential Protection, EFGHI Ring",

author = "Masato Oikawa and Taizo Iwayama and Makoto Sasaki",

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AU - Oikawa, Masato

AU - Iwayama, Taizo

AU - Sasaki, Makoto

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Here, we report a synthesis of a differentially protected, open-chain C21-C40 fragment of azaspiracid-1, corresponding to the lower half EFGHI-ring domain. The synthesis features modular coupling of three advanced intermediates, aiming for diverted analogue synthesis. A new method for construction of E-ring moiety amenable to the diverted synthesis is also reported.

AB - Here, we report a synthesis of a differentially protected, open-chain C21-C40 fragment of azaspiracid-1, corresponding to the lower half EFGHI-ring domain. The synthesis features modular coupling of three advanced intermediates, aiming for diverted analogue synthesis. A new method for construction of E-ring moiety amenable to the diverted synthesis is also reported.

KW - α-Chlorosulfide

KW - Azaspiracid

KW - C21-C40 Fragment

KW - Differential Protection

KW - EFGHI Ring

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EP - 615

JO - Heterocycles

JF - Heterocycles

IS - 3

ER -

Synthesis of open-chain C21-C40 fragment of azaspiracid-1

Abstract

Keywords

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