Synthesis of peptide ribonucleic acid consisting of D- and L-gamma-glutamic acid as a backbone structure.

Takehiko Wada; Yusuke Hashimoto; Hirofumi Sato; Yoshihisa Inoue

Synthesis of peptide ribonucleic acid consisting of D- and L-gamma-glutamic acid as a backbone structure.

Takehiko Wada, Yusuke Hashimoto, Hirofumi Sato, Yoshihisa Inoue

IMRAM - Division of Organic- and Biomaterials Research

Japan Science and Technology Agency

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5-amino-5-deoxyribonucleoside as a recognition site for nucleic acids and consists D-glutamic acid (D-PRNA) instead of L-glutamic acid (L-PRNA) as a backbone structure, has been designed and synthesized. Difference between D-PRNA and L-PRNA oligomers was elucidated on the basis of the effects of chirality of gamma-glutamic acid backbone upon structure elucidated by CD spectra.

Original language	English
Pages (from-to)	27-28
Number of pages	2
Journal	Nucleic acids symposium series (2004)
Issue number	48
Publication status	Published - 2004

Cite this

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title = "Synthesis of peptide ribonucleic acid consisting of D- and L-gamma-glutamic acid as a backbone structure.",

abstract = "A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5-amino-5-deoxyribonucleoside as a recognition site for nucleic acids and consists D-glutamic acid (D-PRNA) instead of L-glutamic acid (L-PRNA) as a backbone structure, has been designed and synthesized. Difference between D-PRNA and L-PRNA oligomers was elucidated on the basis of the effects of chirality of gamma-glutamic acid backbone upon structure elucidated by CD spectra.",

author = "Takehiko Wada and Yusuke Hashimoto and Hirofumi Sato and Yoshihisa Inoue",

year = "2004",

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T1 - Synthesis of peptide ribonucleic acid consisting of D- and L-gamma-glutamic acid as a backbone structure.

AU - Wada, Takehiko

AU - Hashimoto, Yusuke

AU - Sato, Hirofumi

AU - Inoue, Yoshihisa

PY - 2004

Y1 - 2004

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AB - A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5-amino-5-deoxyribonucleoside as a recognition site for nucleic acids and consists D-glutamic acid (D-PRNA) instead of L-glutamic acid (L-PRNA) as a backbone structure, has been designed and synthesized. Difference between D-PRNA and L-PRNA oligomers was elucidated on the basis of the effects of chirality of gamma-glutamic acid backbone upon structure elucidated by CD spectra.

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JO - Nucleic acids symposium series (2004)

JF - Nucleic acids symposium series (2004)

IS - 48

ER -

Synthesis of peptide ribonucleic acid consisting of D- and L-gamma-glutamic acid as a backbone structure.

Abstract

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