Synthesis of polysubstituted naphthalenes by iron-catalyzed [2+2+2] annulation of grignard reagents with alkynes

Laurean Ilies; Arimasa Matsumoto; Motoaki Kobayashi; Naohiko Yoshikai; Eiichi Nakamura

doi:10.1055/s-0032-1317077

Synthesis of polysubstituted naphthalenes by iron-catalyzed [2+2+2] annulation of grignard reagents with alkynes

Laurean Ilies, Arimasa Matsumoto, Motoaki Kobayashi, Naohiko Yoshikai, Eiichi Nakamura

PHA - Molecular Pharmaceutical Science

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Iron catalyzes the oxidative [2+2+2] annulation of an arylmagnesium compound with two molecules of an internal alkyne via C-H bond activation at 0 °C to produce polysubstituted naphthalene.

Original language	English
Article number	ST-2012-U0548-L
Pages (from-to)	2381-2384
Number of pages	4
Journal	Synlett
Volume	23
Issue number	16
DOIs	https://doi.org/10.1055/s-0032-1317077
Publication status	Published - 2012

Keywords

Alkynes
Annulation
C-H bond activation
Iron
Naphthalene

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10.1055/s-0032-1317077

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title = "Synthesis of polysubstituted naphthalenes by iron-catalyzed [2+2+2] annulation of grignard reagents with alkynes",

abstract = "Iron catalyzes the oxidative [2+2+2] annulation of an arylmagnesium compound with two molecules of an internal alkyne via C-H bond activation at 0 °C to produce polysubstituted naphthalene.",

keywords = "Alkynes, Annulation, C-H bond activation, Iron, Naphthalene",

author = "Laurean Ilies and Arimasa Matsumoto and Motoaki Kobayashi and Naohiko Yoshikai and Eiichi Nakamura",

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AU - Ilies, Laurean

AU - Matsumoto, Arimasa

AU - Kobayashi, Motoaki

AU - Yoshikai, Naohiko

AU - Nakamura, Eiichi

PY - 2012

Y1 - 2012

N2 - Iron catalyzes the oxidative [2+2+2] annulation of an arylmagnesium compound with two molecules of an internal alkyne via C-H bond activation at 0 °C to produce polysubstituted naphthalene.

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KW - Alkynes

KW - Annulation

KW - C-H bond activation

KW - Iron

KW - Naphthalene

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ER -

Synthesis of polysubstituted naphthalenes by iron-catalyzed [2+2+2] annulation of grignard reagents with alkynes

Abstract

Keywords

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