Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity.

N. Katagiri; M. Nomura; H. Sato; C. Tameda; A. Kurimoto; S. Arai; A. Toyota; C. Kaneko

Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity.

N. Katagiri, M. Nomura, H. Sato, C. Tameda, A. Kurimoto, S. Arai, A. Toyota, C. Kaneko

PHA - Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS.

Original language	English
Pages (from-to)	5-6
Number of pages	2
Journal	Nucleic acids symposium series
Issue number	25
Publication status	Published - 1991

ASJC Scopus subject areas

Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS.",

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T1 - Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity.

AU - Katagiri, N.

AU - Nomura, M.

AU - Sato, H.

AU - Tameda, C.

AU - Kurimoto, A.

AU - Arai, S.

AU - Toyota, A.

AU - Kaneko, C.

PY - 1991

Y1 - 1991

N2 - The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS.

AB - The 1'- and 5'-hydroxymethyl derivatives of carbovir and related purine derivatives were synthesized from 5-hydroxymethylcyclopentadiene. The anti-HIV activity evaluation of these compounds has revealed that 9-(c-4,t-5-dihydroxymethylcyclopent-2-en-r-1-yl)-9H-adenine is a prospective chemotherapeutic agent against AIDS.

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M3 - Article

C2 - 1842092

AN - SCOPUS:0026387879

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ER -

Synthesis of purine bases having a di(hydroxymethyl)cyclopentenyl group by means of high-pressure reaction and their anti-HIV activity.

Abstract

ASJC Scopus subject areas

UN SDGs

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