Maduropeptin, an extremely potent antitumor agent, consists of a 1:1 complex of a carrier protein and a chromophore. We report herein a general and efficient route for the synthesis of the highly strained bicyclo[7.3.0] dodecadiyne core of the chromophore. The key feature of the synthetic strategy is the use of two Sonogashira coupling reactions in a stepwise manner to construct the conjugated dienyne substructure of the fused-ring system, including the Z alkene at C4,C13.
|Number of pages||7|
|Journal||Chemistry - An Asian Journal|
|Publication status||Published - 2008 Feb 1|
- Antitumor agents
- Natural products
ASJC Scopus subject areas
- Organic Chemistry