Synthetic studies on ciguatoxin: A highly convergent synthesis of the GHIJKLM ring system based on b-alkyl suzuki coupling

Hiroyuki Takakura; Katsuhiko Noguchi; Makoto Sasaki; Kazuo Tachibana

doi:10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W

Synthetic studies on ciguatoxin: A highly convergent synthesis of the GHIJKLM ring system based on b-alkyl suzuki coupling

Hiroyuki Takakura, Katsuhiko Noguchi, Makoto Sasaki, Kazuo Tachibana

LIF - Molecular and Chemical Life Science

The University of Tokyo

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

Access to polycyclic polyethers is facilitated by a synthetic strategy involving two-step B-alkyl Suzuki coupling reactions for the stereo-selective construction of the polyether skeleton. Thus, a convergent synthetic route to the heptacyclic GHIJKLM ring system 1 of ciguatoxin, a marine algal toxin implicated in ciguatera fish poisoning, was developed. Bn = benzyl.

Original language	English
Pages (from-to)	1090-1093
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	6
DOIs	https://doi.org/10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W
Publication status	Published - 2001 Mar 14

Keywords

Ciguatoxin
Cross-coupling
Natural products
Polycycles
Synthetic methods

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/1521-3773(20010316)40:6<1090::AID-ANIE10900>3.0.CO;2-W

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author = "Hiroyuki Takakura and Katsuhiko Noguchi and Makoto Sasaki and Kazuo Tachibana",

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T2 - A highly convergent synthesis of the GHIJKLM ring system based on b-alkyl suzuki coupling

AU - Takakura, Hiroyuki

AU - Noguchi, Katsuhiko

AU - Sasaki, Makoto

AU - Tachibana, Kazuo

PY - 2001/3/14

Y1 - 2001/3/14

N2 - Access to polycyclic polyethers is facilitated by a synthetic strategy involving two-step B-alkyl Suzuki coupling reactions for the stereo-selective construction of the polyether skeleton. Thus, a convergent synthetic route to the heptacyclic GHIJKLM ring system 1 of ciguatoxin, a marine algal toxin implicated in ciguatera fish poisoning, was developed. Bn = benzyl.

AB - Access to polycyclic polyethers is facilitated by a synthetic strategy involving two-step B-alkyl Suzuki coupling reactions for the stereo-selective construction of the polyether skeleton. Thus, a convergent synthetic route to the heptacyclic GHIJKLM ring system 1 of ciguatoxin, a marine algal toxin implicated in ciguatera fish poisoning, was developed. Bn = benzyl.

KW - Ciguatoxin

KW - Cross-coupling

KW - Natural products

KW - Polycycles

KW - Synthetic methods

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Synthetic studies on ciguatoxin: A highly convergent synthesis of the GHIJKLM ring system based on b-alkyl suzuki coupling

Abstract

Keywords

UN SDGs

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