Access to polycyclic polyethers is facilitated by a synthetic strategy involving two-step B-alkyl Suzuki coupling reactions for the stereo-selective construction of the polyether skeleton. Thus, a convergent synthetic route to the heptacyclic GHIJKLM ring system 1 of ciguatoxin, a marine algal toxin implicated in ciguatera fish poisoning, was developed. Bn = benzyl.
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2001 Mar 14|
- Natural products
- Synthetic methods