@article{c08af720eebe4b9a9e3022d8aaa4e980,
title = "Synthetic studies on strictamine: Unexpected oxidation of tertiary amine in Ru-catalyzed ring-closing olefin metathesis",
abstract = "During synthetic studies toward strictamine, unexpected oxidation of tertiary amine to enamine was observed in ring-closing olefin metathesis (RCM) using Hoveyda-Grubbs 2nd catalyst. Control experiments under deoxygenated conditions indicated Ru-catalyst and electron deficient 1,4-benzoquinone additive promoted oxidation. The desired RCM reaction took place selectively under microwave irradiation by suppression of oxidation of amine.",
keywords = "Alkaloid, Amine, Enamine, Olefin metathesis, Oxidation",
author = "Yoshiyuki Komatsu and Kei Yoshida and Hirofumi Ueda and Hidetoshi Tokuyama",
note = "Funding Information: This work was financially supported by the Cabinet Office, Government of Japan through its “Funding Program for Next Generation World-Leading Researchers (LS008), a Grant-in aid for Young Scientists (B) (24790003) (for H.U.), and Tohoku University G-COE program {\textquoteleft}IREMC{\textquoteright}. The authors are grateful to Professor H. Kotsuki of Kochi University for giving Y.K. an opportunity to conduct research at Kochi University after the 3.11 earthquake. ",
year = "2013",
month = jan,
day = "30",
doi = "10.1016/j.tetlet.2012.10.129",
language = "English",
volume = "54",
pages = "377--380",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "5",
}