Systemic increase of oxidative nucleic acid damage in Parkinson’s disease and multiple system atrophy

Akio Kikuchi; Atsushi Takeda; Hiroshi Onodera; Teiko Kimpara; Kinya Hisanaga; Nobuyuki Sato; Akihiko Nunomura; Rudy J. Castellani; George Perry; Mark A. Smith; Yasuto Itoyama

doi:10.1006/nbdi.2002.0466

Systemic increase of oxidative nucleic acid damage in Parkinson’s disease and multiple system atrophy

Akio Kikuchi, Atsushi Takeda, Hiroshi Onodera, Teiko Kimpara, Kinya Hisanaga, Nobuyuki Sato, Akihiko Nunomura, Rudy J. Castellani, George Perry, Mark A. Smith, Yasuto Itoyama

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

217 Citations (Scopus)

Abstract

8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG) a product of oxidized DNA or RNA is a good marker of oxidative cellular damage. In this study we measured the 8-OHdG/8-OHG levels in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Compared to age-matched controls the mean levels of serum 8-OHdG/8-OHG were significantly higher in PD (P < 0.0001). Although no gender differences were observed in the controls the mean values of serum 8-OHdG/8-OHG were significantly higher in female PD cases (P < 0.005) than in male patients. 8-OHdG/8-OHG levels in CSF were also increased significantly in patients with PD and MSA however their relative values were generally much lower than those in the serum. Together with previous studies showing increased peripheral 8-OHdG levels in Alzheimer's disease and amyotrophic lateral sclerosis the data presented here suggest that systemic DNA/RNA oxidation is commonly observed in neurodegenerative diseases. Our results also imply that female patients with PD show higher levels of oxidative stress which may explain the faster progression of this disease in females.

Original language	English
Pages (from-to)	244-248
Number of pages	5
Journal	Neurobiology of Disease
Volume	9
Issue number	2
DOIs	https://doi.org/10.1006/nbdi.2002.0466
Publication status	Published - 2002 Mar

Keywords

8-hydroxy-2′-deoxyguanosine (8-OHdG)/8-hydroxyguanosine (8-OHG)
Oxidative stress
Parkinson's disease

ASJC Scopus subject areas

Neurology

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10.1006/nbdi.2002.0466

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title = "Systemic increase of oxidative nucleic acid damage in Parkinson{\textquoteright}s disease and multiple system atrophy",

abstract = "8-hydroxy-2′-deoxyguanosine (8-OHdG) or 8-hydroxyguanosine (8-OHG) a product of oxidized DNA or RNA is a good marker of oxidative cellular damage. In this study we measured the 8-OHdG/8-OHG levels in the serum and cerebrospinal fluid (CSF) of patients with Parkinson's disease (PD) and multiple system atrophy (MSA). Compared to age-matched controls the mean levels of serum 8-OHdG/8-OHG were significantly higher in PD (P < 0.0001). Although no gender differences were observed in the controls the mean values of serum 8-OHdG/8-OHG were significantly higher in female PD cases (P < 0.005) than in male patients. 8-OHdG/8-OHG levels in CSF were also increased significantly in patients with PD and MSA however their relative values were generally much lower than those in the serum. Together with previous studies showing increased peripheral 8-OHdG levels in Alzheimer's disease and amyotrophic lateral sclerosis the data presented here suggest that systemic DNA/RNA oxidation is commonly observed in neurodegenerative diseases. Our results also imply that female patients with PD show higher levels of oxidative stress which may explain the faster progression of this disease in females.",

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author = "Akio Kikuchi and Atsushi Takeda and Hiroshi Onodera and Teiko Kimpara and Kinya Hisanaga and Nobuyuki Sato and Akihiko Nunomura and Castellani, {Rudy J.} and George Perry and Smith, {Mark A.} and Yasuto Itoyama",

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AU - Kikuchi, Akio

AU - Takeda, Atsushi

AU - Onodera, Hiroshi

AU - Kimpara, Teiko

AU - Hisanaga, Kinya

AU - Sato, Nobuyuki

AU - Nunomura, Akihiko

AU - Castellani, Rudy J.

AU - Perry, George

AU - Smith, Mark A.

AU - Itoyama, Yasuto

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Systemic increase of oxidative nucleic acid damage in Parkinson’s disease and multiple system atrophy

Abstract

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