Systemic lupus erythematosus accompanied by psoriasis induces IL-27-producing cells in both affected areas of the skin

Gen Ichi Tojo; Taku Fujimura; Yumi Kambayashi; Setsuya Aiba

doi:10.1159/000342803

Systemic lupus erythematosus accompanied by psoriasis induces IL-27-producing cells in both affected areas of the skin

Gen Ichi Tojo, Taku Fujimura, Yumi Kambayashi, Setsuya Aiba

MED - Medical Sciences

Tohoku University

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-producing cells in biopsy specimens from both SLE and psoriasis. Our findings might suggest relationships between IL-27 and the pathogenesis of these inflammatory diseases.

Original language	English
Pages (from-to)	181-185
Number of pages	5
Journal	Case Reports in Dermatology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1159/000342803
Publication status	Published - 2012 May

Keywords

Activated antigen-presenting cells
IL-27
Type 1 helper T cells

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10.1159/000342803

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abstract = "IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-producing cells in biopsy specimens from both SLE and psoriasis. Our findings might suggest relationships between IL-27 and the pathogenesis of these inflammatory diseases.",

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AU - Tojo, Gen Ichi

AU - Fujimura, Taku

AU - Kambayashi, Yumi

AU - Aiba, Setsuya

PY - 2012/5

Y1 - 2012/5

N2 - IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-producing cells in biopsy specimens from both SLE and psoriasis. Our findings might suggest relationships between IL-27 and the pathogenesis of these inflammatory diseases.

AB - IL-27 is mainly produced by activated antigen-presenting cells (APCs), and has been reported in various Th1/Th17-mediated inflammatory diseases, including psoriasis, and even in Th2-complexed disease, such as systemic lupus erythematosus (SLE). We describe a 51-year-old Japanese man with SLE accompanied by psoriasis. Interestingly, immunohistochemical staining revealed the existence of IL-27-producing cells in biopsy specimens from both SLE and psoriasis. Our findings might suggest relationships between IL-27 and the pathogenesis of these inflammatory diseases.

KW - Activated antigen-presenting cells

KW - IL-27

KW - Type 1 helper T cells

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Systemic lupus erythematosus accompanied by psoriasis induces IL-27-producing cells in both affected areas of the skin

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Keywords

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