T-cell lymphoma presenting neutrophilic inflammation in the cerebrospinal fluid

Takaaki Nakamura, Yoshiki Takai, Kimihiko Kaneko, Hiroshi Kuroda, Tatsuro Misu, Kiyotaka Asanuma, Ryoko Saito, Masashi Aoki

Research output: Contribution to journalArticlepeer-review


A 66-year-old woman presented with upper abdominal pain and weakness in the limbs. She had bilateral uveitis and gastric ulcers. A neurological examination revealed tetraparesis and sensory disturbance in the right arm. A cerebrospinal fluid (CSF) examination showed polymorphonuclear pleocytosis with elevated proinflammatory cytokine levels. Magnetic resonance imaging showed brain lesions and a long spinal cord lesion. She was initially diagnosed with neuro-Behçet's disease and was treated with corticosteroids, resulting in no improvement. A gastric mucosa biopsy indicated T-cell lymphoma colocalizing with neutrophils. The cytokine-mediated neutrophilic inflammation probably caused characteristic CSF and histopathological features. It is noteworthy that T-cell lymphoma may present with CSF neutrophilic inflammation.

Original languageEnglish
Pages (from-to)573-576
Number of pages4
JournalInternal Medicine
Issue number4
Publication statusPublished - 2020 Feb 15


  • Interleukin-17
  • Interleukin-6
  • Interleukin-8
  • Neuro-Behçet's disease
  • Neuro-neutrophilic disease
  • Polymorphonuclear leukocyte


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