TY - JOUR
T1 - T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline
T2 - The Ohasama Study
AU - Fujiwara, Tohru
AU - Katsuya, Tomohiro
AU - Matsubara, Mitsunobu
AU - Mikami, Tadayoshi
AU - Ishikawa, Kazuhiko
AU - Kikuya, Masahiro
AU - Ohkubo, Takayoshi
AU - Hozawa, Atsushi
AU - Michimata, Mari
AU - Suzuki, Michiko
AU - Metoki, Hirohito
AU - Asayama, Kei
AU - Araki, Tsutomu
AU - Tsuji, Ichiro
AU - Higaki, Jitsuo
AU - Satoh, Hiroshi
AU - Hisamichi, Shigeru
AU - Ogihara, Toshio
AU - Imai, Yutaka
PY - 2002
Y1 - 2002
N2 - Background: We assessed the association between several polymorphisms of angiotensinogen gene (AGT) and essential hypertension using ambulatory blood pressure (BP). Methods: We recruited 802 subjects in a rural Japanese community who were aged >40 years and who gave written informed consent for monitoring of their ambulatory BP and genetic analysis (the Ohasama Study). As a polymorphism of AGT, T+31C, which is in complete linkage disequilibrium with M235T, was determined using the TaqMan polymerase chain reaction method. Results: The genotype distribution of AGT/T+31C in the Ohasama Study was similar to that in another large Japanese population. Although there was no significant difference in 24-h and daytime ambulatory BP values, the nighttime BP was significantly lower in the subjects with TT, resulting in greater decline of nocturnal systolic (P = .090) and diastolic (P = .025) BP in subjects with TT. Conclusions: AGT/T+31C is associated with the circadian BP variation but not with BP level in the Japanese general population.
AB - Background: We assessed the association between several polymorphisms of angiotensinogen gene (AGT) and essential hypertension using ambulatory blood pressure (BP). Methods: We recruited 802 subjects in a rural Japanese community who were aged >40 years and who gave written informed consent for monitoring of their ambulatory BP and genetic analysis (the Ohasama Study). As a polymorphism of AGT, T+31C, which is in complete linkage disequilibrium with M235T, was determined using the TaqMan polymerase chain reaction method. Results: The genotype distribution of AGT/T+31C in the Ohasama Study was similar to that in another large Japanese population. Although there was no significant difference in 24-h and daytime ambulatory BP values, the nighttime BP was significantly lower in the subjects with TT, resulting in greater decline of nocturnal systolic (P = .090) and diastolic (P = .025) BP in subjects with TT. Conclusions: AGT/T+31C is associated with the circadian BP variation but not with BP level in the Japanese general population.
KW - Ambulatory blood pressure
KW - Angiotensinogen
KW - Circadian blood pressure variation
KW - Hypertension
KW - Nocturnal blood pressure decline
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U2 - 10.1016/S0895-7061(02)02944-8
DO - 10.1016/S0895-7061(02)02944-8
M3 - Article
C2 - 12118911
AN - SCOPUS:0036637171
SN - 0895-7061
VL - 15
SP - 628
EP - 632
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 7 I
ER -