T+31C polymorphism of angiotensinogen gene and nocturnal blood pressure decline: The Ohasama Study

Tohru Fujiwara, Tomohiro Katsuya, Mitsunobu Matsubara, Tadayoshi Mikami, Kazuhiko Ishikawa, Masahiro Kikuya, Takayoshi Ohkubo, Atsushi Hozawa, Mari Michimata, Michiko Suzuki, Hirohito Metoki, Kei Asayama, Tsutomu Araki, Ichiro Tsuji, Jitsuo Higaki, Hiroshi Satoh, Shigeru Hisamichi, Toshio Ogihara, Yutaka Imai

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Background: We assessed the association between several polymorphisms of angiotensinogen gene (AGT) and essential hypertension using ambulatory blood pressure (BP). Methods: We recruited 802 subjects in a rural Japanese community who were aged >40 years and who gave written informed consent for monitoring of their ambulatory BP and genetic analysis (the Ohasama Study). As a polymorphism of AGT, T+31C, which is in complete linkage disequilibrium with M235T, was determined using the TaqMan polymerase chain reaction method. Results: The genotype distribution of AGT/T+31C in the Ohasama Study was similar to that in another large Japanese population. Although there was no significant difference in 24-h and daytime ambulatory BP values, the nighttime BP was significantly lower in the subjects with TT, resulting in greater decline of nocturnal systolic (P = .090) and diastolic (P = .025) BP in subjects with TT. Conclusions: AGT/T+31C is associated with the circadian BP variation but not with BP level in the Japanese general population.

Original languageEnglish
Pages (from-to)628-632
Number of pages5
JournalAmerican Journal of Hypertension
Issue number7 I
Publication statusPublished - 2002


  • Ambulatory blood pressure
  • Angiotensinogen
  • Circadian blood pressure variation
  • Hypertension
  • Nocturnal blood pressure decline


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