TY - JOUR
T1 - Telomere and telomerase
T2 - New markers for diagnosis of colorectal cancer
AU - Kinouchi, Y.
AU - Hiwatashi, N.
AU - Chida, M.
AU - Kumagai, S.
AU - Takagi, S.
AU - Negoro, K.
AU - Toyota, T.
PY - 1998
Y1 - 1998
N2 - Telomeres are tandem-repeated DNA sequences located at the ends of eukaryotic chromosomes. Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. Activity of telomerase, a ribonucleoprotein enzyme, is found in most cancer tissues and is generally undetected in normal human somatic tissues. Thus, detection of telomere length and telomerase activity have utility in the early diagnosis of colitic Cancer and colorectal cancer respectively, and telomerase may be a new target for therapeutic intervention.
AB - Telomeres are tandem-repeated DNA sequences located at the ends of eukaryotic chromosomes. Telomere length in human somatic cells gradually decreases with the number of cell divisions and is regarded as a marker of somatic cell turnover. Activity of telomerase, a ribonucleoprotein enzyme, is found in most cancer tissues and is generally undetected in normal human somatic tissues. Thus, detection of telomere length and telomerase activity have utility in the early diagnosis of colitic Cancer and colorectal cancer respectively, and telomerase may be a new target for therapeutic intervention.
KW - Colorectal cancer
KW - Telomerase
KW - Telomere
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U2 - 10.3862/jcoloproctology.51.1113
DO - 10.3862/jcoloproctology.51.1113
M3 - Article
AN - SCOPUS:0031762023
SN - 0047-1801
VL - 51
SP - 1113
EP - 1117
JO - Journal of the Japan Society of Colo-Proctology
JF - Journal of the Japan Society of Colo-Proctology
IS - 10
ER -
