Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders

Nobuya Obana; Sho Takagi; Yoshitaka Kinouchi; Yoshihisa Tokita; Akihiro Sekikawa; Seiichi Takahashi; Nobuo Hiwatashi; Shinichi Oikawa; Tooru Shimosegawa

doi:10.2169/internalmedicine.42.150

Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders

Nobuya Obana, Sho Takagi, Yoshitaka Kinouchi, Yoshihisa Tokita, Akihiro Sekikawa, Seiichi Takahashi, Nobuo Hiwatashi, Shinichi Oikawa, Tooru Shimosegawa

IEHE - Division of Research in Student Support

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

Objective. Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis. Patients and Methods. We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases. Results. The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p=0.0014). Conclusion. Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.

Original language	English
Pages (from-to)	150-153
Number of pages	4
Journal	Internal Medicine
Volume	42
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.42.150
Publication status	Published - 2003 Feb 1

Keywords

Coronary diseases
Diabetes mellitus
Hypercholesterolemia
Telomere

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10.2169/internalmedicine.42.150

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title = "Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders",

abstract = "Objective. Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis. Patients and Methods. We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases. Results. The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p=0.0014). Conclusion. Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.",

keywords = "Coronary diseases, Diabetes mellitus, Hypercholesterolemia, Telomere",

author = "Nobuya Obana and Sho Takagi and Yoshitaka Kinouchi and Yoshihisa Tokita and Akihiro Sekikawa and Seiichi Takahashi and Nobuo Hiwatashi and Shinichi Oikawa and Tooru Shimosegawa",

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T1 - Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders

AU - Obana, Nobuya

AU - Takagi, Sho

AU - Kinouchi, Yoshitaka

AU - Tokita, Yoshihisa

AU - Sekikawa, Akihiro

AU - Takahashi, Seiichi

AU - Hiwatashi, Nobuo

AU - Oikawa, Shinichi

AU - Shimosegawa, Tooru

PY - 2003/2/1

Y1 - 2003/2/1

N2 - Objective. Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis. Patients and Methods. We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases. Results. The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p=0.0014). Conclusion. Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.

AB - Objective. Telomere shortening is correlated with cell turnover and aging, but it has been recently suggested to occur not only by aging but by several biochemical factors of metabolic disorders predisposing to atherosclerosis. Patients and Methods. We compared telomere length of peripheral blood mononuclear cells of patients with the metabolic disorders, hypercholesterolemia (HC) and diabetes mellitus (DM), according to the presence or absence of coronary diseases. Results. The results demonstrated that HC and/or DM patients with coronary diseases have significantly shorter telomere length than healthy controls (p=0.0014). Conclusion. Telomere shortening may be involved in the mechanisms that promote coronary diseases under some circumstances of metabolic disorders.

KW - Coronary diseases

KW - Diabetes mellitus

KW - Hypercholesterolemia

KW - Telomere

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Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders

Abstract

Keywords

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