Attachment of small molecules to large biomolecules can occur through a supramolecular three-body modular-binding scheme (see scheme). This approach allows cucurbituril (C), which normally cannot bind to DNA, to be attached to double-stranded DNA (A) through a linker molecule (B) containing both an acridine moiety (which binds to DNA) and a spermine moiety (which binds cucurbituril).
|Number of pages||4|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - 2000 Dec 4|
- DNA recognition
- Supramolecular chemistry
ASJC Scopus subject areas