Ternary complexes between DNA, polyamine, and cucurbituril: A modular approach to DNA-binding molecules

Hiroyuki Isobe; Naoki Tomita; Jae Wook Lee; Hee Joon Kim; Kimoon Kim; Eiichi Nakamura

doi:10.1002/1521-3773(20001201)39:23<4257::AID-ANIE4257>3.0.CO;2-6

Ternary complexes between DNA, polyamine, and cucurbituril: A modular approach to DNA-binding molecules

Hiroyuki Isobe, Naoki Tomita, Jae Wook Lee, Hee Joon Kim, Kimoon Kim, Eiichi Nakamura

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Attachment of small molecules to large biomolecules can occur through a supramolecular three-body modular-binding scheme (see scheme). This approach allows cucurbit[6]uril (C), which normally cannot bind to DNA, to be attached to double-stranded DNA (A) through a linker molecule (B) containing both an acridine moiety (which binds to DNA) and a spermine moiety (which binds cucurbit[6]uril).

Original language	English
Pages (from-to)	4257-4260
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	39
Issue number	23
DOIs	https://doi.org/10.1002/1521-3773(20001201)39:23<4257::AID-ANIE4257>3.0.CO;2-6
Publication status	Published - 2000 Dec 4

Keywords

DNA recognition
Intercalation
Rotaxanes
Supramolecular chemistry

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/1521-3773(20001201)39:23<4257::AID-ANIE4257>3.0.CO;2-6

Cite this

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title = "Ternary complexes between DNA, polyamine, and cucurbituril: A modular approach to DNA-binding molecules",

abstract = "Attachment of small molecules to large biomolecules can occur through a supramolecular three-body modular-binding scheme (see scheme). This approach allows cucurbit[6]uril (C), which normally cannot bind to DNA, to be attached to double-stranded DNA (A) through a linker molecule (B) containing both an acridine moiety (which binds to DNA) and a spermine moiety (which binds cucurbit[6]uril).",

keywords = "DNA recognition, Intercalation, Rotaxanes, Supramolecular chemistry",

author = "Hiroyuki Isobe and Naoki Tomita and Lee, {Jae Wook} and Kim, {Hee Joon} and Kimoon Kim and Eiichi Nakamura",

year = "2000",

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doi = "10.1002/1521-3773(20001201)39:23<4257::AID-ANIE4257>3.0.CO;2-6",

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T1 - Ternary complexes between DNA, polyamine, and cucurbituril

T2 - A modular approach to DNA-binding molecules

AU - Isobe, Hiroyuki

AU - Tomita, Naoki

AU - Lee, Jae Wook

AU - Kim, Hee Joon

AU - Kim, Kimoon

AU - Nakamura, Eiichi

PY - 2000/12/4

Y1 - 2000/12/4

N2 - Attachment of small molecules to large biomolecules can occur through a supramolecular three-body modular-binding scheme (see scheme). This approach allows cucurbit[6]uril (C), which normally cannot bind to DNA, to be attached to double-stranded DNA (A) through a linker molecule (B) containing both an acridine moiety (which binds to DNA) and a spermine moiety (which binds cucurbit[6]uril).

AB - Attachment of small molecules to large biomolecules can occur through a supramolecular three-body modular-binding scheme (see scheme). This approach allows cucurbit[6]uril (C), which normally cannot bind to DNA, to be attached to double-stranded DNA (A) through a linker molecule (B) containing both an acridine moiety (which binds to DNA) and a spermine moiety (which binds cucurbit[6]uril).

KW - DNA recognition

KW - Intercalation

KW - Rotaxanes

KW - Supramolecular chemistry

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Ternary complexes between DNA, polyamine, and cucurbituril: A modular approach to DNA-binding molecules

Abstract

Keywords

ASJC Scopus subject areas

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