TY - JOUR
T1 - Tetramethylammonium fluoride tetrahydrate-mediated transition metal-free coupling of aryl iodides with unactivated arenes in air
AU - Nozawa-Kumada, Kanako
AU - Nakamura, Kosuke
AU - Kurosu, Satoshi
AU - Iwakawa, Yuki
AU - Denneval, Charline
AU - Shigeno, Masanori
AU - Kondo, Yoshinori
N1 - Funding Information:
Acknowledgments This work was financially supported
Funding Information:
This work was financially supported by the Japan Society for the Promotion of Science (JSPS) KAKENHI Grant No. 17K15418. This work was also supported by Grand for Basic Science Research Projects from The Sumitomo Foundation, the Platform Project for Supporting Drug Discovery and Life Science Research funded by Japan Agency for Medical Research and Development (AMED), Tohoku University Center for Gender Equality Promotion (TUMUG), and Morinomiyako Project for Empowering Women in Research.
Publisher Copyright:
© 2019 The Pharmaceutical Society of Japan.
PY - 2019
Y1 - 2019
N2 - Biaryls are important compounds with widespread applications in many fields. Tetramethylammonium fluoride tetrahydrate was found to promote the biaryl coupling of aryl iodides bearing electron-withdrawing substituents with unactivated arenes. The reaction takes place at temperatures between 100 and 150°C and can be applied to a wide range of aromatic and heteroaromatic rings, affording the products in moderate to high yields. The reaction does not require strong bases or expensive additives that are employed in the existing methods and can be conducted in air and moisture without any precautions.
AB - Biaryls are important compounds with widespread applications in many fields. Tetramethylammonium fluoride tetrahydrate was found to promote the biaryl coupling of aryl iodides bearing electron-withdrawing substituents with unactivated arenes. The reaction takes place at temperatures between 100 and 150°C and can be applied to a wide range of aromatic and heteroaromatic rings, affording the products in moderate to high yields. The reaction does not require strong bases or expensive additives that are employed in the existing methods and can be conducted in air and moisture without any precautions.
KW - Biaryl
KW - Tetramethylammonium fluoride tetrahydrate
KW - Transition-metal-free coupling
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U2 - 10.1248/cpb.c19-00452
DO - 10.1248/cpb.c19-00452
M3 - Letter
C2 - 31582624
AN - SCOPUS:85072705762
SN - 0009-2363
VL - 67
SP - 1042
EP - 1045
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 10
ER -