TY - JOUR
T1 - Tetrodotoxin in Asian newts (Salamandridae)
AU - Yotsu-Yamashita, Mari
AU - Toennes, Stefan W.
AU - Mebs, Dietrich
N1 - Funding Information:
This work was funded by Grant-in-Aid for Scientific Research (B) (no. 26292057 and 17H03809) from Japan Society for the Promotion of Science to M. Y. Y.
PY - 2017/8
Y1 - 2017/8
N2 - Tetrodotoxin (TTX) and its analogues occur in a wide range of marine animals but also in terrestrial vertebrates such as frogs, toads and newts. Despite numerous studies on TTX in New World newts (Notophthalmus viridescens, Taricha spp.), few data only exist for Asian newts. Methanolic extracts of newts from China (Cynops orientalis, Pachytriton labiatus, Paramesotriton chinensis), Vietnam (Paramesotriton deloustali, P. guangxiensis), and Laos (Laotriton laoensis) were analyzed by liquid-chromatography-fluorescent detection (LC-FLD) and mass-spectrometry (LC-MS). In all species, variable amounts of TTX were detected, in most specimens also TTX-analogues like 6-epiTTX, in C. orientalis 11-oxoTTX, confirming the presence of these toxins in modern Asian newts.
AB - Tetrodotoxin (TTX) and its analogues occur in a wide range of marine animals but also in terrestrial vertebrates such as frogs, toads and newts. Despite numerous studies on TTX in New World newts (Notophthalmus viridescens, Taricha spp.), few data only exist for Asian newts. Methanolic extracts of newts from China (Cynops orientalis, Pachytriton labiatus, Paramesotriton chinensis), Vietnam (Paramesotriton deloustali, P. guangxiensis), and Laos (Laotriton laoensis) were analyzed by liquid-chromatography-fluorescent detection (LC-FLD) and mass-spectrometry (LC-MS). In all species, variable amounts of TTX were detected, in most specimens also TTX-analogues like 6-epiTTX, in C. orientalis 11-oxoTTX, confirming the presence of these toxins in modern Asian newts.
KW - 11-Oxotetrodotoxin
KW - 6-Epitetrodotoxin
KW - Asian newts
KW - Cynops spp.
KW - Laotriton laoensis
KW - Pachytriton labiatus
KW - Paramesotriton spp.
KW - Tetrodotoxin
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U2 - 10.1016/j.toxicon.2017.05.014
DO - 10.1016/j.toxicon.2017.05.014
M3 - Article
C2 - 28528177
AN - SCOPUS:85019548001
SN - 0041-0101
VL - 134
SP - 14
EP - 17
JO - Toxicon
JF - Toxicon
ER -
