Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-α

Juan Feng; Tatsuro Misu; Kazuo Fujihara; Naoko Misawa; Yoshio Koyanagi; Yusei Shiga; Atsushi Takeda; Shigeru Sato; Sadao Takase; Takeshi Kohnosu; Hiroshi Saito; Yasuto Itoyama

doi:10.1016/j.jneuroim.2004.02.007

Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-α

Juan Feng, Tatsuro Misu, Kazuo Fujihara, Naoko Misawa, Yoshio Koyanagi, Yusei Shiga, Atsushi Takeda, Shigeru Sato, Sadao Takase, Takeshi Kohnosu, Hiroshi Saito, Yasuto Itoyama

HOSP - Neurological and Psychiatric Disorders

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

We studied the immunological and virological effects of interferon-α (IFN-α) therapy in nine patients with HTLV-I-associated myelopathy (HAM/TSP). After therapy, the percentages of CCR5+ cells in CD4+ cells significantly decreased in the cerebrospinal fluid as well as blood. The therapy also significantly lowered the intracellular IFN-γ+/interleukin-4+ T-cell ratio in blood. Those helper T-cell type 1 (Th1)-related responses tended to be higher and reduce more evidently following therapy in three patients who clinically improved. Also, all the three patients had one or more HTLV-I copies in five blood mononuclear cells. These results suggest that IFN-α suppresses Th1 responses in HAM/TSP and that the patients with higher Th1 immunity and proviral loads may be responders of the therapy. Larger-scale studies are needed to confirm the findings.

Original language	English
Pages (from-to)	189-194
Number of pages	6
Journal	Journal of Neuroimmunology
Volume	151
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.02.007
Publication status	Published - 2004 Jun

Keywords

Chemokine receptor
HAM/TSP
HTLV-I
Helper T cell
Interferon-alpha therapy

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10.1016/j.jneuroim.2004.02.007

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title = "Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-α",

abstract = "We studied the immunological and virological effects of interferon-α (IFN-α) therapy in nine patients with HTLV-I-associated myelopathy (HAM/TSP). After therapy, the percentages of CCR5+ cells in CD4+ cells significantly decreased in the cerebrospinal fluid as well as blood. The therapy also significantly lowered the intracellular IFN-γ+/interleukin-4+ T-cell ratio in blood. Those helper T-cell type 1 (Th1)-related responses tended to be higher and reduce more evidently following therapy in three patients who clinically improved. Also, all the three patients had one or more HTLV-I copies in five blood mononuclear cells. These results suggest that IFN-α suppresses Th1 responses in HAM/TSP and that the patients with higher Th1 immunity and proviral loads may be responders of the therapy. Larger-scale studies are needed to confirm the findings.",

keywords = "Chemokine receptor, HAM/TSP, HTLV-I, Helper T cell, Interferon-alpha therapy",

author = "Juan Feng and Tatsuro Misu and Kazuo Fujihara and Naoko Misawa and Yoshio Koyanagi and Yusei Shiga and Atsushi Takeda and Shigeru Sato and Sadao Takase and Takeshi Kohnosu and Hiroshi Saito and Yasuto Itoyama",

note = "Funding Information: The authors thank Mr. Brent Bell for reading the manuscript. This work was supported by the grants from the Ministry of Education, Science, Culture, Sports and Technology and the Tawara's Endowment for HAM Research.",

year = "2004",

month = jun,

doi = "10.1016/j.jneuroim.2004.02.007",

language = "English",

volume = "151",

pages = "189--194",

journal = "Journal of Neuroimmunology",

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T1 - Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-α

AU - Feng, Juan

AU - Misu, Tatsuro

AU - Fujihara, Kazuo

AU - Misawa, Naoko

AU - Koyanagi, Yoshio

AU - Shiga, Yusei

AU - Takeda, Atsushi

AU - Sato, Shigeru

AU - Takase, Sadao

AU - Kohnosu, Takeshi

AU - Saito, Hiroshi

AU - Itoyama, Yasuto

N1 - Funding Information: The authors thank Mr. Brent Bell for reading the manuscript. This work was supported by the grants from the Ministry of Education, Science, Culture, Sports and Technology and the Tawara's Endowment for HAM Research.

PY - 2004/6

Y1 - 2004/6

N2 - We studied the immunological and virological effects of interferon-α (IFN-α) therapy in nine patients with HTLV-I-associated myelopathy (HAM/TSP). After therapy, the percentages of CCR5+ cells in CD4+ cells significantly decreased in the cerebrospinal fluid as well as blood. The therapy also significantly lowered the intracellular IFN-γ+/interleukin-4+ T-cell ratio in blood. Those helper T-cell type 1 (Th1)-related responses tended to be higher and reduce more evidently following therapy in three patients who clinically improved. Also, all the three patients had one or more HTLV-I copies in five blood mononuclear cells. These results suggest that IFN-α suppresses Th1 responses in HAM/TSP and that the patients with higher Th1 immunity and proviral loads may be responders of the therapy. Larger-scale studies are needed to confirm the findings.

AB - We studied the immunological and virological effects of interferon-α (IFN-α) therapy in nine patients with HTLV-I-associated myelopathy (HAM/TSP). After therapy, the percentages of CCR5+ cells in CD4+ cells significantly decreased in the cerebrospinal fluid as well as blood. The therapy also significantly lowered the intracellular IFN-γ+/interleukin-4+ T-cell ratio in blood. Those helper T-cell type 1 (Th1)-related responses tended to be higher and reduce more evidently following therapy in three patients who clinically improved. Also, all the three patients had one or more HTLV-I copies in five blood mononuclear cells. These results suggest that IFN-α suppresses Th1 responses in HAM/TSP and that the patients with higher Th1 immunity and proviral loads may be responders of the therapy. Larger-scale studies are needed to confirm the findings.

KW - Chemokine receptor

KW - HAM/TSP

KW - HTLV-I

KW - Helper T cell

KW - Interferon-alpha therapy

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Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-α

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Keywords

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