TY - JOUR
T1 - The 1975 Japanese diet has a stress reduction effect in mice
T2 - Search for physiological effects using metabolome analysis
AU - Iwagaki, Yui
AU - Sugawara, Saeko
AU - Huruya, Yasuhisa
AU - Sato, Miki
AU - Wu, Qiming
AU - Shuang, E.
AU - Yamamoto, Kazushi
AU - Tsuduki, Tsuyoshi
N1 - Funding Information:
This work was supported by grants from the Project of the NARO Bio-oriented Technology Research Advancement Institution (Advanced integration research for agriculture and interdisciplinary fields); The Canon Foundation; Integration Research for Agriculture and Interdisciplinary Fields and Integration Development Research for Agriculture and Interdisciplinary Fields, Ministry of Agriculture, Forestry and Fisheries of Japan; The Canon Foundation.
Publisher Copyright:
© 2018 Japan society for Bioscience, Biotechnology, and agrochemistry.
PY - 2018
Y1 - 2018
N2 - We aimed to find new physiological effects of the Japanese diet. First, to determine the key components in serum from mice fed the 1975 diet, serum from mice fed the 1960, 1975, 1990 or 2005 Japanese diet was analyzed using CE-TOFMS and LC-TOFMS. Based on these results, the key components were determined by principal component analysis. Among the identified compounds, GABA was included. Therefore, a stress reduction effect was inferred as a novel physiological effect of this diet. Next, we tested whether the 1975 diet had an actual stress reduction effect in mice. Mice were given the 1975 diet or a control diet for 4 weeks, after which they were divided into restraint stress and non-stress groups. Mice fed the 1975 diet had significantly decreased stress parameters compared with those fed the control diet. These results provide the first evidence that the 1975 Japanese diet has a stress reduction effect.
AB - We aimed to find new physiological effects of the Japanese diet. First, to determine the key components in serum from mice fed the 1975 diet, serum from mice fed the 1960, 1975, 1990 or 2005 Japanese diet was analyzed using CE-TOFMS and LC-TOFMS. Based on these results, the key components were determined by principal component analysis. Among the identified compounds, GABA was included. Therefore, a stress reduction effect was inferred as a novel physiological effect of this diet. Next, we tested whether the 1975 diet had an actual stress reduction effect in mice. Mice were given the 1975 diet or a control diet for 4 weeks, after which they were divided into restraint stress and non-stress groups. Mice fed the 1975 diet had significantly decreased stress parameters compared with those fed the control diet. These results provide the first evidence that the 1975 Japanese diet has a stress reduction effect.
KW - Ce-toFms(capillary electrophoresis time-of-flight mass spectrometry)
KW - Lc-toFms(liquid chromatography time-of-flight mass spectrometry)
KW - Principal component analysis
KW - Stress
KW - The Japanese diet
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U2 - 10.1080/09168451.2017.1417022
DO - 10.1080/09168451.2017.1417022
M3 - Article
C2 - 29307274
AN - SCOPUS:85045001858
SN - 0916-8451
VL - 82
SP - 709
EP - 715
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 4
ER -