The antihistamine olopatadine regulates T cell activation in palladium allergy

Naohiko Iguchi, Yuri Takeda, Naoki Sato, Kenichirou Ukichi, Akira Katakura, Kyosuke Ueda, Takayuki Narushima, Shigehito Higuchi, Kouetsu Ogasawara

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Because of its corrosion resistance palladium (Pd) has been widely used in many consumer products ranging from fashion accessories to dental materials. Recently, however, an increase in Pd allergy cases has been reported. Metal allergy is categorized as a Type IV allergy, which is characterized as a delayed-type hypersensitivity reaction in which T cells are known to play an important role; however, the precise mechanism of their action remains unclear. Here we defined the relationship between histamine and the Pd allergic reaction specifically with respect to T cell responses. To verify the effects of histamine on T cells, we examined whether there is a change in IFN-γ production following stimulation of histamine or the antihistamine, olopatadine hydrochloride (OLP), in vitro. In addition, we assessed whether OLP administration affected the degree of footpad swelling or IFN-γ production during the Pd allergy response in mice. We found that histamine stimulation increased IFN-γ production in T cells, specifically enhancing IFN-γ production in CD8+ T cells compared with CD4+ T cells. Interestingly, OLP suppressed the production of IFN-γ in CD8+ T cells, and this compound inhibited footpad swelling and IFN-γ production in mice with Pd allergy. These results suggest that histamine promotes the Type IV allergic reaction and thus, the histamine 1 receptor (H1R) might be useful therapeutic target for treatment of metal allergy.

Original languageEnglish
Pages (from-to)70-76
Number of pages7
JournalInternational Immunopharmacology
Publication statusPublished - 2016 Jun


  • Histamine
  • Histamine 1 receptor (H1R)
  • Olopatadine hydrochloride (OLP)
  • Palladium allergy

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology


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