The ASK1-MAP kinase pathways in immune and stress responses

Teruyuki Hayakawa; Atsushi Matsuzawa; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo

doi:10.1016/j.micinf.2005.12.001

The ASK1-MAP kinase pathways in immune and stress responses

Teruyuki Hayakawa, Atsushi Matsuzawa, Takuya Noguchi, Kohsuke Takeda, Hidenori Ichijo

PHA - Life and Pharmaceutical Science

The University of Tokyo

Research output: Contribution to journal › Short survey › peer-review

82 Citations (Scopus)

Abstract

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.

Original language	English
Pages (from-to)	1098-1107
Number of pages	10
Journal	Microbes and Infection
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/j.micinf.2005.12.001
Publication status	Published - 2006 Apr

Keywords

Apoptosis signal-regulating kinase 1
Inflammation
Innate immunity
MAP kinase cascades
Oxidative stresses

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2005.12.001

Cite this

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title = "The ASK1-MAP kinase pathways in immune and stress responses",

abstract = "Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.",

keywords = "Apoptosis signal-regulating kinase 1, Inflammation, Innate immunity, MAP kinase cascades, Oxidative stresses",

author = "Teruyuki Hayakawa and Atsushi Matsuzawa and Takuya Noguchi and Kohsuke Takeda and Hidenori Ichijo",

year = "2006",

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AU - Hayakawa, Teruyuki

AU - Matsuzawa, Atsushi

AU - Noguchi, Takuya

AU - Takeda, Kohsuke

AU - Ichijo, Hidenori

PY - 2006/4

Y1 - 2006/4

N2 - Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.

AB - Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.

KW - Apoptosis signal-regulating kinase 1

KW - Inflammation

KW - Innate immunity

KW - MAP kinase cascades

KW - Oxidative stresses

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U2 - 10.1016/j.micinf.2005.12.001

DO - 10.1016/j.micinf.2005.12.001

M3 - Short survey

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AN - SCOPUS:33646143763

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EP - 1107

JO - Microbes and Infection

JF - Microbes and Infection

IS - 4

ER -

The ASK1-MAP kinase pathways in immune and stress responses

Abstract

Keywords

UN SDGs

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