The ASK1-MAP kinase pathways in immune and stress responses

Teruyuki Hayakawa, Atsushi Matsuzawa, Takuya Noguchi, Kohsuke Takeda, Hidenori Ichijo

Research output: Contribution to journalShort surveypeer-review

82 Citations (Scopus)


Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase which plays pivotal roles in stress and immune responses. This review is focused on three major subjects on ASK1: the regulatory mechanisms of the kinase activity, the pathophysiological roles in stress response and innate immunity, and the evolutionary perspectives.

Original languageEnglish
Pages (from-to)1098-1107
Number of pages10
JournalMicrobes and Infection
Issue number4
Publication statusPublished - 2006 Apr


  • Apoptosis signal-regulating kinase 1
  • Inflammation
  • Innate immunity
  • MAP kinase cascades
  • Oxidative stresses


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