TY - JOUR
T1 - The benefit of chemotherapy in a patient with multiple brain metastases and meningitis carcinomatosa from ovarian cancer
AU - Watanabe, Ayako
AU - Shimada, Muneaki
AU - Kigawa, Junzo
AU - Iba, Takahiro
AU - Oishi, Tetsuro
AU - Kanamori, Yasunobu
AU - Terakawa, Naoki
PY - 2005/2
Y1 - 2005/2
N2 - We report on a 45-year-old patient with stage IIIc ovarian cancer, multiple brain metastases, and meningitis carcinomatosa. After three courses of initial chemotherapy, consisting of docetaxel and carboplatin, the patient underwent interval cytoreductive surgery, consisting of hyster-ectomy, bilateral salpingo-oophorectomy, omentectomy, appendectomy, and retroperitoneal lymphadenectomy. Then five courses of the same chemotherapy were given as adjuvant treatment. At the completion of the primary therapy, she achieved a complete remission. Ten months after the completion of the initial treatment, multiple brain metastases with meningitis carcinomatosa were detected. After four courses of the same chemotherapy, she again had a complete response, confirmed by cranial enhanced magnetic resonance imaging (MRI), and she felt well, with relief from the debilitating neurologic symptoms for 4 months. After this 4 months, her disease recurred, with meningitis carcinomatosa, and she requested supportive care only. She died 4 months after this recurrence. Chemotherapy can help to prolong life for some patients with multiple brain metastases and meningitis carcinomatosa from ovarian cancer.
AB - We report on a 45-year-old patient with stage IIIc ovarian cancer, multiple brain metastases, and meningitis carcinomatosa. After three courses of initial chemotherapy, consisting of docetaxel and carboplatin, the patient underwent interval cytoreductive surgery, consisting of hyster-ectomy, bilateral salpingo-oophorectomy, omentectomy, appendectomy, and retroperitoneal lymphadenectomy. Then five courses of the same chemotherapy were given as adjuvant treatment. At the completion of the primary therapy, she achieved a complete remission. Ten months after the completion of the initial treatment, multiple brain metastases with meningitis carcinomatosa were detected. After four courses of the same chemotherapy, she again had a complete response, confirmed by cranial enhanced magnetic resonance imaging (MRI), and she felt well, with relief from the debilitating neurologic symptoms for 4 months. After this 4 months, her disease recurred, with meningitis carcinomatosa, and she requested supportive care only. She died 4 months after this recurrence. Chemotherapy can help to prolong life for some patients with multiple brain metastases and meningitis carcinomatosa from ovarian cancer.
KW - Brain metastasis
KW - Chemotherapy
KW - Meningitis carcinomatosa
KW - Ovarian cancer
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U2 - 10.1007/s10147-004-0437-x
DO - 10.1007/s10147-004-0437-x
M3 - Article
C2 - 15729605
AN - SCOPUS:15044365200
SN - 1341-9625
VL - 10
SP - 69
EP - 71
JO - International Journal of Clinical Oncology
JF - International Journal of Clinical Oncology
IS - 1
ER -
